4-アミノ-1-TERT-ブチル-3-(3-メチルベンジル)ピラゾロ[3,4-D]ピリミジン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P330：口をすすぐこと。

  P501：内容物/容器を．．．に廃棄すること。

4-アミノ-1-TERT-ブチル-3-(3-メチルベンジル)ピラゾロ[3,4-D]ピリミジン 価格

4-アミノ-1-TERT-ブチル-3-(3-メチルベンジル)ピラゾロ[3,4-D]ピリミジン 化学特性,用途語,生産方法

• 化学的特性

  White Solid

• 使用

  A highly potent and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase

• 一般的な説明

  A cell-permeable C₃-enlarged PP1 (Cat. No. 567809) analog that is shown to act as a potent, ATP-competitive, and highly ASKA- (analog-sensitive kinase alleles) selective inhibitor against polo-like kinase 1^{C67V L130G} (75% and 94% inhibition in cell-free kinase assays at 0.1 and 1 μM, respectively), ZAP-70^{C405V M414A}/ZAP-70^M414A (complete prevention and elimination, respectively, of αTCR-stimulated [Ca²⁺] elevation in ASKA transfectants when applied before or after αTCR stimulation at 6 μM), and Syk^{M442A S505A} (56% inhibition of phagocytosis of Ab-opsonized SRBC by ASKA macrophages at 6 μM), while exhibiting little or no activity toward the wild-type or other off-target cellular enzymes. Functional analog-sensitive allele mutants are valuable tools in pharmacological validation of drug development and in elucidating enzyme signalings and functions both in cultures in vitro and in animals in vivo when specific inhibitors against naturally occurring target enzymes are unavailable and/or generations of knockout animals/cells lacking the target enzymes appear to be difficult, infeasible, or simply impossible.

4-アミノ-1-TERT-ブチル-3-(3-メチルベンジル)ピラゾロ[3,4-D]ピリミジン 生産企業

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4-アミノ-1-TERT-ブチル-3-(3-メチルベンジル)ピラゾロ[3,4-D]ピリミジン スペクトルデータ(¹HNMR)