2-フルオロ-3-ニトロ安息香酸メチル
化学名:2-フルオロ-3-ニトロ安息香酸メチル
CAS番号.946126-94-9
英語名:methyl 2-fluoro-3-nitrobenzoate
CBNumberCB81553204
MFC8H6FNO4
MW199.14
MOL File946126-94-9.mol
别名
2-フルオロ-3-ニトロ安息香酸メチル
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2-フルオロ-3-ニトロ安息香酸メチル物理性質
| 融点 | 77- 80° C |
| 沸点 | 310.8±27.0 °C(Predicted) |
| 比重(密度) | 1.388±0.06 g/cm3(Predicted) |
| 貯蔵温度 | Sealed in dry,Room Temperature |
| 溶解性 | クロロホルム（微量）、メタノール（微量） |
| 外見 | 個体 |
| 色 | オフホワイトからペールイエロー |
A solution of 2-fluoro-3-nitrobenzoic acid (5 g, 27.0 mmol) in MeOH (50 mL) was treated with concentrated H2SO4 (1.4 mL, 27.0 mmol) and the resulting reaction was stirred at 50 °C for 16 h. The solvent was removed under reduced pressure and the residue was diluted with EtO Ac. The organic solution was washed with saturated aqueous NaHCO3 solution until the water phase reached neutral pH. The two phases were separated. Organics were washed with water, brine and dried (Na2SO4). The solution was filtered and concentrated to give crude methyl 2-fluoro-3-nitrobenzoate which was used as is in the next step. (5.1 g, 25.2 mmol, 93 %) as a pale yellow solid.