(2S)-2-ヒドロキシグルタル酸二ナトリウム塩

(2S)-2-ヒドロキシグルタル酸二ナトリウム塩 価格

(2S)-2-ヒドロキシグルタル酸二ナトリウム塩 化学特性,用途語,生産方法

• 説明

  L-α-Hydroxyglutaric acid (L-2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels. L-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation.

• 化学的特性

  White Solid

• 使用

  A potential inhibitor of glutamate carboxypeptidase.

• 一般的な説明

  Glutamic acid is metabolized to α-Hydroxyglutaric acid in an NAD-dependent manner by cell-free extracts of Peptococcus aerogenes. It is formed as an intermediate during glyoxylic acid metabolism in bacteria.

(2S)-2-ヒドロキシグルタル酸二ナトリウム塩 生産企業

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(2S)-2-ヒドロキシグルタル酸二ナトリウム塩 スペクトルデータ(¹HNMR)

63512-50-5, (2S)-2-ヒドロキシグルタル酸二ナトリウム塩 キーワード