4-クロロレソルシノール

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H302：飲み込むと有害

  H315：皮膚刺激

  H317：アレルギー性皮膚反応を起こすおそれ

  H318：重篤な眼の損傷

  H412：長期的影響により水生生物に有害

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P273：環境への放出を避けること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

4-クロロレソルシノール 価格

MSDS Information

• 4-Chloro-1,3-dihydroxybenzene

4-クロロレソルシノール 化学特性,用途語,生産方法

• 外観

  わずかにうすい褐色～赤褐色、結晶性粉末～粉末

• 定義

  本品は、レゾルシン(*)の塩化物であり、次の化学式で表される。
  参照表示名称：レゾルシン

• 用途

  有機合成原料。

• 化粧品の成分用途

  毛髪着色剤

• 化学的特性

  4-Chlororesorcinol is a colorless crystals or off-white to light brown powder. The melting point is 89°C (106.5-107.5°C), the boiling point is 259°C, 147°C (2.4kPa). Soluble in water, alcohol, ether, benzene and carbon disulfide. Can sublimate. It reacts with ferric chloride to generate blue-purple.

• 使用

  4-Chlororesorcinol, can be used as hair dye formulation. It can also be used in the synthesis of series of six coumarin compounds carrying halogen and trifluoromethyl, having antifungal activities.

• 主な応用

  In cosmetics and personal care products, 4-Chlororesorcinol is used in the formulation of hair dyes, colors and tints.
  4-Chlororesorcinol is used in permanent hair coloring systems where color is produced inside the hair fiber. This is accomplished through careful formulation of the product so that the ingredients interact in a highly controlled process.

• 製造方法

  4-Chlororesorcinol is synthesized by reacting resorcinol with dichlorosulfuryl. Resorcinol and diethyl ether were mixed, heated to reflux with stirring, and dichlorosulfuryl was slowly added dropwise. The temperature was then raised to 60°C for 1 h. After recovery of ether, atmospheric distillation is carried out, the distillate is subjected to vacuum distillation again, and the 131°C (0.8-0.93kPa) or 160-164°C (4.0kPa) fractions are collected to obtain the finished 4-chlororesorcinol.

• 安全性

  4-chlororesorcinol is classified as a toxic substance and exposure to high concentration of 4-chlororesorcinol could cause several health issues including, skin irritation, serious eye irritation, and other hazards.
  The safety of 4-Chlororesorcinol has been assessed by the Cosmetic Ingredient Review (CIR) Expert Panel. The CIR Expert Panel evaluated the scientific data and concluded that 4-Chlororesorcinol was safe in hair dye formulations.
  The CIR Expert Panel concluded that the scientific data suggested that 4-Chlororesorcinol can be safely used in hair dye products. Subchronic dermal exposure to a hair dye product containing 2% 4-Chlororesorcinol produced no evidence of compound-induced toxicity. At the same concentration, no development effects, no evidence of reproductive toxicity, and no carcinogenic effects were seen following dermal exposure. Likewise, 4-Chlororesorcinol was not mutagenic in either a micronucleus or in bacteria, nor did it induce aneuploidy in fungus cells. A 2.5% solution was not a dermal irritant or an ocular irritant.

• 純化方法

  Crystallise it from boiling CCl4 (10g/L, charcoal) and dry it in air. [Beilstein 6 II 818.] IRRITANT.

4-クロロレソルシノール 上流と下流の製品情報

4-クロロレソルシノール 生産企業

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4-クロロレソルシノール スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、MS)

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