CATENIN Β、GSTタグ融合 ヒト

CATENIN Β、GSTタグ融合 ヒト 価格

CATENIN Β、GSTタグ融合 ヒト 化学特性,用途語,生産方法

• 使用

  Catenin β, GST tagged human has been used:
  
  • as a component of protein kinase buffer for in vitro kinase assay
  • in in vitro?citrullination assay to characterize β-catenin citrullination
  • to perform differentiation factor screening
  
  

• 一般的な説明

  β-catenins are cytoplasmic proteins that are ubiquitously expressed. These proteins associate with E-cadherin at cellular junctions. CTNNB1 (catenin β-1) belongs to the armadillo family of proteins. This protein possesses a 130 amino acid N-terminal domain, 12 imperfect repeats of 42 amino acids termed arm repeats and a 100 amino acid C-terminal domain. The gene encoding β-catenin is localized on human chromosome 3p22.1.

• Biochem/physiol Actions

  β-catenin interacts with T-cell factor and lymphoid enhancer-binding factor (TCF and LEF) transcription factors and is an essential member of the Wingless-Wnt signal transduction pathway. The adenomatous polyposis coli (APC) tumor-suppressor protein, together with Axin and glycogen synthase kinase 3 β (GSK3β), form a Wnt-regulated signaling complex that mediates phosphorylation-dependent degradation of βcatenin by the proteasome. APC and the Siah-1 E3 ubiquitin-protein ligase-1 mediate a novel β-catenin degradation pathway linking p53 activation to cell cycle control. Activating mutations in the human β-catenin gene have been found in human colon cancer and melanomas. The protein has a role in homeostasis and development.

CATENIN Β、GSTタグ融合 ヒト 生産企業

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