2,3,4,9-テトラヒドロ-1H-カルバゾール-3-アミン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H315：皮膚刺激

  H319：強い眼刺激

  H332：吸入すると有害

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

2,3,4,9-テトラヒドロ-1H-カルバゾール-3-アミン 価格

2,3,4,9-テトラヒドロ-1H-カルバゾール-3-アミン 化学特性,用途語,生産方法

• Synthesis Reference(s)

  Journal of Heterocyclic Chemistry, 22, p. 191, 1985 DOI: 10.1002/jhet.5570220146

• 合成

  3-Amino-1,2,3,4-tetrahydrocarbazol is prepared by the reaction of 1,4-dioxaspiro[4.5]decan-8-amine and phenylhydrazine. The specific synthesis steps are as follows:
  General procedure: Aqueous sulfuric acid solution (10 % w/v, 30 mL) was taken in a round bottom flask, added (1,4-dioxa-spiro[4.5]dec-8-yl)dimethylamine (12a, 1.5 g, 8.1 mmol) followed by phenylhydrazine (1.52 g, 14.08 mmol) at room temperature. The reaction mass was heated to reflux temperature (95-100 °C) and maintained reflux for 2-3 h. The progress of the reaction was monitored by TLC. After completion of reaction, the reaction mass was cooled to 10-15 °C. Then the mass was basified with aqueous sodium hydroxide solution (20 % w/v) and the aqueous layer was extracted with ethyl acetate. Organic layer was washed with brine solution, dried over anhydrous sodium sulfate and organic volatiles were removed by distillation under vacuum. The crude compound was purified by flash chromatography (ethyl acetate: triethylamine 9:0.2) to obtain 0.8 g of 3-Amino-1,2,3,4-tetrahydrocarbazol (13a), the yield being 50 %.
  

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