Bis(maltolato)oxovanadium(IV)

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H301：飲み込むと有毒

• 注意書き

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

Bis(maltolato)oxovanadium(IV) 価格

Bis(maltolato)oxovanadium(IV) 化学特性,用途語,生産方法

• 化学的特性

  Dark Purple Solid

• 使用

  It is a potent insulin mimic. Results showed that a promising outlook as an oral glucose-lowering drug.

• 応用例（製薬）

  Bis(maltolato)oxovanadium (BMOV) has proven itself as a successful antidiabetic agent when tested in animalmodels. Nevertheless, only very little is known about its mode of action. It is believed that BMOV acts as a competitive and reversible inhibitor of the enzyme protein tyrosine phosphatase (PTP).
  As previously mentioned, BMOV is believed to be a potent and competitive inhibitor of the PTP1B activity and additionally seem to support the autophosphorylation of the insulin receptor leading to an increased sensitivity towards insulin. Research has shown that varying the organic ligand has an influence on the effectiveness and bioavailability of the resulting vanadium compound. It is believed that factors such as absorption, tissue uptake and distribution are affected most. Interestingly enough, X-ray crystal data of PTP1B soaked with BMOV showed only vanadate [V(+V)O₄^3?] at the active site. This would emphasise that the organic ligands are only carriers of the active compound and play no role in the enzyme inhibition itself. Furthermore, in aqueous solution, V(IV) is rapidly and reversibly oxidised to V(V), supporting the possible formation of vanadate.

Bis(maltolato)oxovanadium(IV) 生産企業

Global(78)Suppliers

38213-69-3, Bis(maltolato)oxovanadium(IV) キーワード