イバブラジン塩酸塩

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H400：水生生物に強い毒性

• 注意書き

  P273：環境への放出を避けること。

イバブラジン塩酸塩 価格

イバブラジン塩酸塩 化学特性,用途語,生産方法

• 外観

  白色～わずかにうすい褐色、結晶性粉末～粉末

• 用途

  If チャンネル阻害剤です。心 臓の収縮機能や血圧に影響を及ぼすさず、心 拍数を低下させます。

• 効能

  強心薬

• 説明

  In an effort to develop angina agents without the unwanted negative inotropic and hypotensive effects associated with b-adrenergic blockers and calcium channel blockers, a new class of heart-rate reducing compounds that act specifically on the sinoatrial (SA) node has been explored. These bradycardic agents interact directly with the pacemaking cell of the SA node and the hyperpolarization- activated If , the primary pacemaking current. Ivabradine has evolved as a specific inhibitor of If current through its contact with f-channels on the intracellular side of the plasma membrane. As a consequence, ivabradine reduces the speed of diastolic depolarization and decreases heart rate. It has been approved for the treatment of chronic stable angina and provides a viable alternative to patients with a contraindication or intolerance of b-blockers. Evaluation is also underway for the potential treatment of ischemic heart disease. Using a patch-clamp technique on rabbit sinoatrial node cells, inhibition of If current ranged from 6% (0.03 mM) – 80% (10 mM). .

• 化学的特性

  White to Off-White Solid

• 使用

  Ivabradine hydrochloride has been used as a potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel (HCN)2 blocker in embryoid body (EB) and rat engineered heart tissue (EHT).

• 定義

  ChEBI: A hydrochloride obtained by combining ivabradine with one molar equivalent of hydrochloric acid. Used to treat patients with angina who have intolerance to beta blockers and/or heart failure.

イバブラジン塩酸塩 上流と下流の製品情報

イバブラジン塩酸塩 生産企業

Global(462)Suppliers

イバブラジン塩酸塩 スペクトルデータ(¹HNMR)

148849-67-6, イバブラジン塩酸塩 キーワード