6β-(アセトキシ)-3β-(β-D-グルコピラノシルオキシ)-8,14-ジヒドロキシブファ-4,20,22-トリエノリド

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H300：飲み込むと生命に危険

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

  P321：特別な処置が必要である（このラベルの．．． を見よ）。

  P330：口をすすぐこと。

  P405：施錠して保管すること。

  P501：内容物/容器を．．．に廃棄すること。

6β-(アセトキシ)-3β-(β-D-グルコピラノシルオキシ)-8,14-ジヒドロキシブファ-4,20,22-トリエノリド 化学特性,用途語,生産方法

• 説明

  Red squill (Urginea maritima) is a large onionlike plant that grows in coastal regions along the Mediterranean Sea and in the United States; it contains a variety of cardiac glycosides, including scilliroside. All parts of the plant contain scilliroside but it is most concentrated in the bulb. There is also a white squill whose bulbs are white. Red squill has long been known and used medicinally. The earliest reference to red squill is in the Ebers Papyrus as treatment for dropsy (heart failure). Use as treatment for cough, arthritis, general diuretic, and emetic has also been described. Medicinal use declined during the nineteenth century because foxglove (digitalis) was revealed to be safer and more efficacious in the treatment of heart failure. However, use of red squill as a folk medicinal remedy continues, and deaths and serious illness may occur. Red squill is one of the oldest rodenticides and has been in use since the thirteenth century. However, scilliroside has extremely poor palatability, and many rats learn to avoid the bait. Since 1989, rodenticides containing red squill are not approved for use in the United States.

• 使用

  Rat poisonings containing scilliroside continue to be available and used worldwide. Technical-grade red squill powders can contain up to 28% scilliroside, and baits typically contain 0.01–0.07% of the toxicant.

• Toxicity evaluation

  Red squill has a multitude of toxic effects. It is directly irritating to the gastric mucosa, contributing to nausea, vomiting, abdominal pain, diarrhea, and anorexia. Rats are not able to vomit, contributing to the perceived selectivity of toxicity in rats. Scilliroside and scillaren A are both cardiac glycosides, and, like digoxin, inhibit Na+/K+ ATPase, block AV conduction, and may cause a slowed or rapid heart rate and abnormal heart rhythms.

6β-(アセトキシ)-3β-(β-D-グルコピラノシルオキシ)-8,14-ジヒドロキシブファ-4,20,22-トリエノリド 生産企業

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