マンデロニトリル

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H318：重篤な眼の損傷

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

マンデロニトリル 価格

マンデロニトリル 化学特性,用途語,生産方法

• 外観

  白色/無色～黄色粉末～塊～透明液体

• 解説

  α-hydroxybenzeneacetonitrile．C8H7NO(133.14)．ベンズアルデヒドシアノヒドリンともいう．アミグダリン，そのほかの配糖体として高等植物に広く分布している．(R)-，(S)-，およびラセミ体がある．(R)-マンデロニトリルはモモのつぼみに存在する．"無色の針状結晶．融点28.5～29.5 ℃．[α]_D＋46.9°(ベンゼン)．高温か弱アルカリ性で容易にラセミ化する．(R,S)-マンデロニトリルはベンズアルデヒドにシアン化水素を付加すると得られる．無色の柱状結晶．融点22 ℃．d²⁰₄ 1.1165．エタノール，エーテルに易溶，水に不溶．加水分解するとマンデル酸になる．LD50 116 mg/kg(ラット，経口)．[CAS 613-88-7:(R,S)-マンデロニトリル]
  森北出版「化学辞典（第2版）

• 化学的特性

  reddish-brown liquid. D,L-Mandelonitrile [532-28-5], benzaldehyde cyanohydrin, a-cyano-a-hydroxymethylbenzene, C6H5 – CH(OH) – CN, Mr 133.15, mp-10℃, d204 1.1165 – 1.120, is miscible with ethanol and diethyl ether, immiscible with water. Mandelonitrile occurs naturally as the bglycoside of gentiobiose (amygdalin). It decomposes on heating into benzaldehyde and hydrogen cyanide. It is produced from benzaldehyde and alkali cyanide in the presence of mineral acid. Mandelonitrile is used as an intermediate in the production of mandelic acid.

• 天然物の起源

  Mandelonitrile, is a yellow, oily liquid, insoluble in water, but soluble in alcohol and diethyl ether. Mandelonitrile is a component of the glycoside amygdalin, a precursor of laetrile found in the leaves and seeds on most Prunus species (plum, peach, apricot, etc). In 1832, mandelonitrile was the first cyanohydrin to be synthesized. It is commercially prepared from benzaldehyde and hydrogen cyanide. Mandelonitrile is used by certain insects (tiger beetles, an African millipede) as a defense fluid. After expelling the fluid an enzyme catalyzes the conversion of mandelonitrile to benzaldehyde and HCN, which is usually fatal to the insect’s enemy.

• 使用

  Mandelonitrile has been used to extract mandeloamide by the nitrilase variants.

• 定義

  ChEBI: Mandelonitrile is a cyanohydrin that is phenylacetonitrile in which one of the methylene hydrogens is replaced by a hydroxy group.

• 一般的な説明

  Reddish-brown to dark red-brown liquid.

• 空気と水の反応

  Mandelonitrile is sensitive to moisture. . Insoluble in water.

• 反応プロフィール

  Nitriles, such as Mandelonitrile, may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.

• 健康ハザード

  TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

• 火災危険

  Mandelonitrile is combustible.

• 安全性プロファイル

  Poison by intravenous and subcutaneous routes. Mutation data reported. A severe eye irritant. When heated to decomposition it emits toxic fumes of NOx and CN-. See also NITRILES.

• 毒性学

  Mandelonitrile is rather toxic with an LD50 value (rat, oral) of 116 mg/kg. This high toxicity may be due to the equilibrium of the cyanohydrin with benzaldehyde and hydrogen cyanide.

マンデロニトリル 上流と下流の製品情報

マンデロニトリル 生産企業

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マンデロニトリル スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、MS、Raman)

532-28-5, マンデロニトリル キーワード