1,3-ブタンジオール

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H319：強い眼刺激

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P337+P313：眼の刺激が続く場合：医師の診断/手当てを受けること。

1,3-ブタンジオール 価格

MSDS Information

• 1,3-Butanediol

1,3-ブタンジオール 化学特性,用途語,生産方法

• 外観

  無色澄明の液体

• 定義

  BGは、1,3-ブチレングリコールの表示名称である。本品は、次の化学式で表される二価アルコールである。

• 溶解性

  水, エタノール, アセトンに易溶。エーテルに殆ど不溶。水、エタノール及びアセトンに溶けやすく、ジエチルエーテルにほとんど溶けない。

• 用途

  有機合成原料。

• 用途

  樹脂原料、界面活性剤

• 化粧品の成分用途

  減粘剤、皮膚コンディショニング剤、溶剤、香料

• 効能

  溶解剤

• 使用上の注意

  吸湿性が強い

• 化学的特性

  colourless liquid

• 使用

  1,3-Butanediol is used in the synthesis of colchicine derivatives as anticancer agents. Also used in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as euglycem ic agents in the treatment of diabetes.

• 定義

  ChEBI: A butanediol compound having two hydroxy groups in the 1- and 3-positions.

• 製造方法

  From formaldehyde and propylene via pressure and a catalyst.

• 調製方法

  Butylene glycol is prepared by catalytic hydrogenation of aldol using Raney nickel.

• 一般的な説明

  (±)-1,3-Butanediol (BD) is a 1,3-diol. Its vapor pressure upto 270kPa, liquid-phase densities over a temperature range, two-phase (liquid + vapor) heat capacities, critical temperature and critical density have been determined. The obtained data was employed to derive various thermophysical properties.

• 化学性质

  无色粘稠液体，具有吸湿性

• 応用例（製薬）

  Butylene glycol is used as a solvent and cosolvent for injectables. It is used in topical ointments, creams, and lotions, and it is also used as a vehicle in transdermal patches. Butylene glycol is a good solvent for many pharmaceuticals, especially estrogenic substances.
  In an oil-in-water emulsion, butylene glycol exerts its best antimicrobial effects at ～8% concentration. Higher concentrations above 16.7% are required to inhibit fungal growth.

• 接触アレルゲン

  This dihydric alcohol is used for its humectant and preservative potentiator properties in cosmetics, topical medicaments and polyurethane, polyester, cellophane, and cigarettes. It has similar properties, but is less irritant than propylene glycol. Contact allergies seem to be rare.

• 副作用

  1,3-Butanediol is commonly used as a solvent in food flavourings and is mildly toxic by oral and subcutaneous routes, with possible side effects including severe respiratory problems, coma, amnesia, belligerence, confusion, agitation, vomiting, seizures and very slow heartbeat. People who use butylene glycol on a regular basis and then stop using it may also experience withdrawal symptoms such as sleep problems (insomnia), tremors and anxiety.

• 安全性プロファイル

  Mdly toxic by ingestion and subcutaneous routes. A skin and eye irritant. See also ETHYLENE GLYCOL. Experimental reproductive effects. Combustible when exposed to heat or flame. Incompatible with oxidizing materials. To fight fire, use foam, alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.

• 安全性

  Butylene glycol is used in a wide variety of cosmetic formulations and is generally regarded as a relatively nontoxic material. It is mildly toxic by oral and subcutaneous routes.
  In topical preparations, butylene glycol is regarded as minimally irritant. Butylene glycol can cause allergic contact dermatitis, with local sensitivity reported in patch tests. Some local irritation is produced on eye contact.
  LD₅₀ (guinea pig, oral): 11.0 g/kg
  LD₅₀ (mouse, oral): 12.98 g/kg
  LD₅₀ (rat, oral): 18.61 g/kg
  LD₅₀ (rat, SC): 20.0 g/kg

• 発がん性

  There were no tumors found in the 2-year feeding studies on dogs and rats . Thus, it appears that 1,3-butanediol is not carcinogenic.

• 貯蔵

  Butylene glycol is hygroscopic and should be stored in a well-closed container in a cool, dry, well-ventilated place. When heated to decomposition, butylene glycol emits acrid smoke and irritating fumes.

• 合成方法

  通过环氧丙烷和1,3-丁二醇的反应制得

• 不和合性

  Butylene glycol is incompatible with oxidizing reagents.

• 規制状況(Regulatory Status)

  GRAS listed. Included in the FDA Inactive Ingredients Database (transdermal patches). Included in licensed medicines in the UK (topical gel patches/medicated plasters).

1,3-ブタンジオール 上流と下流の製品情報

1,3-ブタンジオール 生産企業

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1,3-ブタンジオール スペクトルデータ(¹HNMR、¹³CNMR、IR1、MS、Raman)

107-88-0, 1,3-ブタンジオール キーワード