4-ホスホノ-3-アザブタン酸

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H312：皮膚に接触すると有害

  H318：重篤な眼の損傷

  H411：長期的影響により水生生物に毒性

• 注意書き

  P273：環境への放出を避けること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P391：漏出物を回収すること。

4-ホスホノ-3-アザブタン酸 価格

MSDS Information

• Bronco

4-ホスホノ-3-アザブタン酸 化学特性,用途語,生産方法

• 解説

  グリホサート（glyphosate）アミノ酸系除草剤の一種。グリシンにホスホノメチルというリン酸が結合した構造をもつ。芳香族アミノ酸の合成を阻害して、植物を枯死させる。1970年に米国の農業化学会社が開発。商品名はラウンドアップ。グリホセート。グリシンとクロロメチルホスホン酸とを水酸化ナトリウムの存在下で反応させ，これを酸析すると得られる．無色の結晶．分解点189～190 ℃．水溶解度11.6 g L－1(25 ℃)．pKa1 2.27，pKa2 5.57，pKa3 10.25(25 ℃)．フェニルアラニンなどの芳香族アミノ酸生合成過程の鍵酵素である，5-(エノールピルボイル)シキミ酸3-リン酸合成酵素(EC 2.5.1.19)を阻害することで植物を枯殺する．グリホサートは，除草剤耐性の遺伝子変換作物にも使用される．イソプロピルアミン塩が広く用いられている．LD50 4320 mg/kg(ラット，経口)．

• 用途

  農薬(除草剤) (NITE CHRIP)

• 説明

  Glyphosate (N-(phosphonomethyl)glycine; 1071-83-6) is the active ingredient in several commercial herbicides for nonselective weed control. Glyphosate herbicides are among the world’s most widely used herbicides. Roundup?, containing the active ingredient glyphosate, was developed and introduced by Monsanto Company in 1974. Other formulations include WeatherMax, UltraMAX, Buccaneer, Razor Pro, Rodeo, and AquaMaster?. Some crops such as soybeans and cotton have been genetically engineered to be resistant to glyphosate (Roundup Ready), allowing farmers to use glyphosate as a postemergence herbicide. The United States Environmental Protection Agency (EPA) considers glyphosate to be relatively low in toxicity compared to organochlorine and organophosphate pesticides.

• 化学的特性

  Glyphosate is a broad-spectrum, non-selective systemic herbicide. It is a colorless crystal at room temperature and is soluble in acetone, ethanol, xylene, and water. Glyphosate is used for the control of annual and perennial plants, including grasses, sedges, broadleaved weeds, and woody plants. It can be used on non-cropland as well as on many varieties of crops. Glyphosate itself is an acid, but it is commonly used in salt form, most commonly isopropylamine salt. It may also be available in acidic or trimethylsulfonium salt forms. It is generally distributed as water-soluble concentrates and powders. Glyphosate is a GUP.

• 使用

  Glyphosate is the active ingredient in several commercial herbicides. It is a broad-spectrum systemic herbicide for various types of weeds, grasses (Poaceae), and woody plants.

• 一般的な説明

  Odorless white powder. Decomposition begins at approximately 419°F (darkens). pH (1% solution in water) 2.5.

• 反応プロフィール

  Glyphosate may react with galvanized steel or unlined steel (except stainless steel) containers to produce hydrogen gas which may form a highly combustible or explosive gas mixture. Glyphosate can react with caustic (basic) materials to liberate heat. Glyphosate is corrosive to iron.

• 健康ハザード

  Glyphosate is practically non-toxic if ingested, with a reported acute oral LD50 of 5600 mg/kg in the rat. The toxicities of the technical acid (glyphosate) and the formulated product (Roundup) are nearly the same. Laboratory animals, such as rats, dogs, mice, and rabbits, exposed to glyphosate for 2 years did not indicate any kind of adverse health effects.

• 火災危険

  Flash point data for Glyphosate are not available; however, Glyphosate is probably combustible.

• 薬理学

  Glyphosate is the only known inhibitor of the biosynthesis of aromatic acids that has been commercialized as a successful herbicide (1). Glyphosate acts as a competitive inhibitor of phosphoenolpyruvate, the natural substrate of the enzyme 5-enolpyruvyl-shikimate-3-phosphate (EPSP) synthase, and causes amassive accumulation of shikimate in treated plant tissue (1).
  Glyphosate is a nonselective herbicide, and it has been characterized as a low-risk herbicide for the evolution of herbicide resistance. A few weed species are somewhat tolerant to glyphosate, probably due to uptake or translocation mechanisms, but no plant species has sufficient resistance to glyphosate to allow its use directly on the crop as a selective herbicide. The complicated procedure used to genetically engineer the commercialized glyphosate-tolerant crops (31) would suggest that the evolution of glyphosate-resistant weeds will be a very slow process and that the level of resistance from field selection will be relatively low.

• 安全性プロファイル

  Poison by intraperitoneal route. Moderately toxic by ingestion. Human systemic effects: arrhythmias, blood pressure lowering, body temperature increase, change in heart rate, convulsions, darrhea, fibrosing alveolitis, fibrosis, hypermoultty, respiratory depression, respiratory stimulation. Used as an herbicide. When heated to decomposition it emits very toxic fumes of NOx and POx.

• 職業ばく露

  A potential danger to those involved in the manufacture, formulation, and application of this nonselective and nonresidual pre-emergence organophos phate herbicide. Has wide residential use in the United States for the control of weeds.

• 代謝経路

  The photolytic degradation of glyphosate results in the formation of glycine, (aminomethyl)phosphonic acid (AMPA), and NH3. Glyphosate undergoes nitrogen ? carbon cleavage on reaction with m- chloroperoxybenzoic acid, leading ultimately to many of the same products formed on their metabolism and environmental degradation. It is suggested that insoluble complexes of glyphosate with iron(III), copper(II), calcium, and magnesium ions are formed at near-neutral pH, a mechanism of which is the inactivation of glyphosate in contaminated groundwater.268 The bacterium degrades high levels of glyphosate, primarily by converting to AMPA. Appreciable uptake of glyphosate is observed with seedlings and leaves and to a lesser extent with culture cells in the form of non-metabolized glyphosate, with AMPA as the only detectable metabolite.

• 代謝

  In soils, glyphosate is rapidly mineralized within 1 to 2 weeks, and degradation occurs under aerobic and anaerobic conditions (79). The C?P bond is relatively resistant to chemical degradation, but several bacteria, e.g., Arthrobacter (80), Pseudomonas (81), various members of the Rhizobiaceae family (82), and certain fungi (83), have been shown to metabolize glyphosate.

• 輸送方法

  UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous haz ardous material, Technical Name Required.

• 不和合性

  Organophosphates are susceptible to for mation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water, and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithio carbamates, isocyanates, mercaptans, nitrides, sulfides (releasing heat, toxic, and possibly flammable gases), thio sulfates, and dithionites (releasing hydrogen sulfate and oxides of sulfur). Solutions are corrosive to iron, unlined steel, and galvanized steel, forming a highly combustible or explosive gas mixture. Do not store glyphosate in contain ers made from these materials.

4-ホスホノ-3-アザブタン酸 上流と下流の製品情報

4-ホスホノ-3-アザブタン酸 生産企業

Global(619)Suppliers

4-ホスホノ-3-アザブタン酸 スペクトルデータ(¹HNMR、¹³CNMR、IR、Raman)

1071-83-6, 4-ホスホノ-3-アザブタン酸 キーワード