4-ヒドロキシブタン酸ナトリウム

化学名:4-ヒドロキシブタン酸ナトリウム

CAS番号.502-85-2

英語名:SODIUM 4-HYDROXYBUTYRATE

CBNumberCB7491645

MFC4H9NaO3

MW128.1

MOL File502-85-2.mol

别名

γ-ヒドロキシ酪酸ナトリウム

4-ヒドロキシブタン酸ナトリウム

ナトリウム4-ヒドロキシブチラート

4-ヒドロキシブタン酸ナトリウム物理性質

融点	145-146°C
闪点	9℃
貯蔵温度	Controlled Substance, -20°C Freezer
溶解性	DMSO (Slightly), Water (Slightly)
外見	個体
Merck	13,4840
CAS データベース	502-85-2(CAS DataBase Reference)
EPAの化学物質情報	Butanoic acid, 4-hydroxy-, monosodium salt (502-85-2)

安全性情報

主な危険性	F,T
Rフレーズ	11-23/24/25-39/23/24/25
Sフレーズ	22-24/25-45-36/37-16-7
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	2
RTECS 番号	ET4750000
F	3
国連危険物分類	IRRITANT
毒性	Highly sol in aq solns. LD50 in male, female rats (mg/kg): 2,000, 1,650 i.p. (Bruguerolle)

危険有害性情報のコード(GHS)

4-ヒドロキシブタン酸ナトリウム化学特性,用途語,生産方法

効能
補助麻酔薬
説明
Xyrem is distributed by Jazz Pharmaceuticals, Inc. (Palo Alto, CA). It is an oral solution of sodium oxybate prescribed for narcoleptic patients to treat extreme daytime sleepiness and cataplexy. Xyrem is also known as sodium oxybate which is the same as gamma hydroxybutyric acid (GHB), a drug of abuse. GHB is endogenously produced and present in the central nervous system (CNS) in small concentrations. Accidental overdosing has led to many hospitalizations and deaths. Because of the tendency to abuse GHB, it was classified as a schedule I controlled substance. This meant that GHB had a high potential for abuse and no medical purpose. However, in 2002, because of a series of clinical trials that demonstrated that the compound reduces cataplexy attacks, it was approved for use under the trademark Xyrem. Since GHB had previously been used as a ‘date-rape’ drug, Xyrem is considered a schedule III controlled substance and is distributed in accordance with strict FDA regulations. Xyrem may only be ordered through the ‘Xyrem Success Program.’ Illegal use is punishable under federal and state laws.
化学的特性
white crystalline powder
使用
4-Hydroxybutyric acid sodium salt is an agonist to both GHB and GABAB neural receptors, exhibiting neurotransmitter-like effects. It has been used as a general anesthetic in treatment for sleep disorders and clinical depression, but also has been identified as a “date rape drug”.
環境運命予測
Xyrem is a water-soluble white to off-white powder, which can be disposed by dumping the oral solution down the sanitary sewer system. This is the preferred method of disposal for drugs which have a high potential for abuse and/or accidental overdose.

4-ヒドロキシブタン酸ナトリウム上流と下流の製品情報

4-ヒドロキシブタン酸ナトリウム生産企業

4-ヒドロキシブタン酸ナトリウムスペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、IR3)

502-85-2, 4-ヒドロキシブタン酸ナトリウムキーワード

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4-ヒドロキシブタン酸ナトリウム

危険有害性情報のコード(GHS)

4-ヒドロキシブタン酸ナトリウム 化学特性,用途語,生産方法

4-ヒドロキシブタン酸ナトリウム 上流と下流の製品情報

4-ヒドロキシブタン酸ナトリウム 生産企業

4-ヒドロキシブタン酸ナトリウム スペクトルデータ(1HNMR、13CNMR、IR1、IR2、IR3)

502-85-2, 4-ヒドロキシブタン酸ナトリウム キーワード

4-ヒドロキシブタン酸ナトリウム化学特性,用途語,生産方法

4-ヒドロキシブタン酸ナトリウム上流と下流の製品情報

4-ヒドロキシブタン酸ナトリウム生産企業

4-ヒドロキシブタン酸ナトリウムスペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、IR3)

502-85-2, 4-ヒドロキシブタン酸ナトリウムキーワード