3-[2-(ピペリジン-4-イル)エチル]-1H-インドール

3-[2-(ピペリジン-4-イル)エチル]-1H-インドール 化学特性,用途語,生産方法

• 説明

  Indalpine is a non-tricyclic antidepressant with a serotonin selective profile. It is 6-7 times more potent than fluoxetine and clomipramine in inhibiting serotonin reuptake in vitro in rat brain synaptosomes. Statistically significant clinical effects within one week of onset of treatment have been reported. An anxiolytic effect may accompany the antidepressant effect. Indalpine appears devoid of anticholinergic and cardiovascular side effects and does not promote weight gain or affect appetite.

• 世界保健機関（WHO）

  Indalpine, an antidepressant with serotoninergic action, was introduced in 1983 and marketed exclusively in France. In 1984 its use was associated with cases of leucopenia and agranulocytosis which led to the voluntary suspension of clinical trials in the USA. In 1985 the major manufacturer voluntarily withdrew the drug from the market.

3-[2-(ピペリジン-4-イル)エチル]-1H-インドール 生産企業

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