Recombinant murine IL-2 is produced in E. coli and exhibits the following:
Supports the growth of murine CTLL cells (murine T cell line), but not that of human T-cells.
Strongly inhibits the binding of recombinant human IL-2 to murine responder cells.
Weakly inhibits the binding to human responder cells.
Shares identical biological and immunological activities with human IL-2.
Is a convenient tool for extensive studies of the pharmacological and physiological activities of IL-2 in murine models.
used for the stimulation of murine T-cells
一般的な説明
Interleukin-2 (IL-2, also known as T-cell growth factor, TCGF) is a lymphokine produced by lectin- or antigen-activated T-cells. It plays an important immunoregulatory role. This factor was first identified by its ability to promote the long-term in vitro proliferation of activated T-cells. It also promotes the generation and proliferation of cytotoxic T-cells, natural killer (NK) cells, and lymphokine-activated killer (LAK) cells. IL-2 also induces other lymphokines such as interferon-γ and B-cell growth factor (BCGF-1).
