ジメチルホスフィンオキシド

化学名:ジメチルホスフィンオキシド

CAS番号.7211-39-4

英語名:DIMETHYLPHOSPHINE OXIDE

CBNumberCB7447743

MFC2H7OP

MW78.05

MOL File7211-39-4.mol

别名

ジメチルホスフィンオキシド

(メチルホスホノイル)メタン

ジメチルホスフィンオキシド物理性質

沸点	65-67 °C(Press: 6 Torr)
貯蔵温度	under inert gas (nitrogen or Argon) at 2–8 °C
外見	液体
色	白色固体から淡黄色
Sensitive	air sensitive
InChI	InChI=1S/C2H7OP/c1-4(2)3/h4H,1-2H3
InChIKey	HGDIHUZVQPKSMO-UHFFFAOYSA-N
SMILES	P(=O)(C)C

危険有害性情報のコード(GHS)

ジメチルホスフィンオキシド化学特性,用途語,生産方法

説明
Dimethylphosphine oxide is an organophosphorus compound. It can be used for the preparation of triacrylphosphine oxide. It can be used as an asymmetric catalyst. In addition, it can be used for the preparation of alkenyldiphenylphosphine oxides, and Horner-Witting reagents. In addition, it is also a kind of capping ligand in organic chemistry.
化学的特性
Dimethylphosphine oxide is a colorless liquid that soluble in polar organic solvents.It exists as the phosphine oxide, not the hydroxy tautomer.
使用
Dimethylphosphine Oxide is used in preparation of substituted piperazine derivatives as DGKα/DGKζ inhibitors for the treatment of viral infections and cancer. It is also used as an organic synthetic raw material for the preparation of (α-aminoalkyl)dimethylphosphine oxide enantiomers. Asymmetric synthesis of α-amino-α-polyfluoroalkyl dimethylphosphine oxides was accomplished through diastereoselective addition of dimethylphosphine oxide to enantiomeric Ellman's aldimines, RFCH=NS(O)tert-Bu (RF=CF3, CHF2, PhCF2).
主な応用
Dimethylphosphine oxide (DMPO) is a hydrogen bonding receptor that can be used to prepare ALK inhibitor compounds (WX-0593) containing DMPO molecules. The results of enzyme assay experiments showed that WX-0593 has high activity against wild-type and mutant ALK, and also inhibits ROS1WT in Ba/F3 cell line very well. In addition, WX-0593 is currently undergoing a phase I/II trial in ALK-positive NSCLC and is expected to be used for the treatment of ROS1-positive NSCLC.
反応性
Chlorination gives dimethylphosphoryl chloride. It undergoes hydroxymethylation with formaldehyde. Me2P(O)H+CH2O→Me2P(O)CH2OH Many aldehydes effect a similar reaction.
参考文献
https://en.wikipedia.org/wiki/Dimethylphosphine_oxide
http://www.sigmaaldrich.com/catalog/product/aldrich/287881?lang=en&region=US
Ganesan, Paramasivam, and S. Lakshmipathi. "Impact of heterogeneous passivation of trimethylphosphine oxide and di-methylphosphine oxide surface ligands on the electronic structure of Cd n Se n, (n =6, 15) quantum dots: A DFT study." Physica E: Low-dimensional Systems and Nanostructures 83(2016):284-296.

ジメチルホスフィンオキシド上流と下流の製品情報

ジメチルホスフィンオキシド生産企業

7211-39-4, ジメチルホスフィンオキシドキーワード

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ジメチルホスフィンオキシド

危険有害性情報のコード(GHS)

ジメチルホスフィンオキシド 化学特性,用途語,生産方法

ジメチルホスフィンオキシド 上流と下流の製品情報

ジメチルホスフィンオキシド 生産企業

7211-39-4, ジメチルホスフィンオキシド キーワード

ジメチルホスフィンオキシド化学特性,用途語,生産方法

ジメチルホスフィンオキシド上流と下流の製品情報

ジメチルホスフィンオキシド生産企業

7211-39-4, ジメチルホスフィンオキシドキーワード