4-(3,4-ジクロロ-2,5-ジオキソ-3-ピロリン-1-イル)安息香酸イソプロピル

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

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4-(3,4-ジクロロ-2,5-ジオキソ-3-ピロリン-1-イル)安息香酸イソプロピル 化学特性,用途語,生産方法

• 説明

  Platelet-activating factor (PAF) is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC₅₀s = 0.47 versus 3.02 μM for human LPCAT2 and LPCAT1, respectively). At 60 μM it was shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore.

• 使用

  TSI-01 is a selectve inhibitor of LPCAT2, a platelet-activiating factor acetyltransferase (PAFAT) which acts as a pro-inflammatory phospholipid mediator. Inhibition leads to suppression of PAF biosynthesis.

4-(3,4-ジクロロ-2,5-ジオキソ-3-ピロリン-1-イル)安息香酸イソプロピル 生産企業

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