抗アミロイド前駆体タンパク質, C末端抗体 ウサギ宿主抗体

抗アミロイド前駆体タンパク質, C末端抗体 ウサギ宿主抗体 価格

抗アミロイド前駆体タンパク質, C末端抗体 ウサギ宿主抗体 化学特性,用途語,生産方法

• 使用

  SH-SY5Y cell lysates were analyzed by western blot using rabbit anti-Amyloid Precursor Protein, C-Terminal as the primary antibody at a 1:500 dilution.

• 一般的な説明

  Amyloid precursor proteins (APPs) are transmembrane glycoproteins that are found in a wide range of tissues. APPs have 3 main isoforms, namely, APP695, APP751 and APP770 that are derived from alternative splicing events in cells. It is expressed at high levels in the brain. APP gene is mapped to human chromosome 21q11.2-q21. It is a 695 amino acid protein which possesses a large ectodomain and comparatively short intracellular region.

• Biochem/physiol Actions

  Amyloid precursor proteins (APPs) regulates cell growth, motility, neurite outgrowth and cell survival. The intracellular C-terminus of APP serves as a transcriptional regulator and as a receptor for kinesin-1-mediated axonal transport. Alzheimer′s disease is characterized by deposition of amyloid in the central nervous system, in neurite plaques and on cerebral vasculature. Mutations in the APP gene are linked with rare forms of autosomal dominant familial Alzheimer′s Disease (FAD). APPs undergo post-translational processing including N- and O-glycosylation, phosphorylation and sulfation.

抗アミロイド前駆体タンパク質, C末端抗体 ウサギ宿主抗体 生産企業

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