MilbeMycin A3 OxiMe

MilbeMycin A3 OxiMe 化学特性,用途語,生産方法

• 説明

  Milbemycin A₃ oxime is an anthelmintic, a derivative of milbemycin A₃ , and a component of milbemycin oxide . It reduces the number of microfilariae of the heartworm D. immitis in the blood of naturally infested dogs by 85.2% when administered at a dose of 0.05 mg/kg. Formulations containing milbemycin A₃ oxime, in combination with milbemycin A₄ oxime, have been used in the treatment of parasitic infections in dogs.

• 使用

  Milbemycin A3 oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of a mixture of milbemycin A3. Milbemycin A3 oxime is the minor component (~30%) in the commercial product milbemycin oxime, marketed for endo- and exo-parasite infections. Like the other milbemycin/avermectins, milbemycin A3 oxime acts by opening glutamate sensitive chloride channels in neurons of invertebrates leading to paralysis by hyperpolarisation of these cells and signal transfer blocking.

MilbeMycin A3 OxiMe 生産企業

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114177-14-9, MilbeMycin A3 OxiMe キーワード