N-((1-(2-(TERT-ブチルアミノ)-2-オキソエチル)ピペリジン-4-イル)メチル)-3-クロロ-5-フルオロベンズアミド

N-((1-(2-(TERT-ブチルアミノ)-2-オキソエチル)ピペリジン-4-イル)メチル)-3-クロロ-5-フルオロベンズアミド 価格

N-((1-(2-(TERT-ブチルアミノ)-2-オキソエチル)ピペリジン-4-イル)メチル)-3-クロロ-5-フルオロベンズアミド 化学特性,用途語,生産方法

• 説明

  Z944 is an inhibitor of T-type calcium channels (IC₅₀s = 0.050-0.160 μM for the human recombinant voltage-gated calcium (Ca_v) channels Ca_v3.1, Ca_v3.2, and Ca_v3.3). It is selective for T-type channels over the N-type Ca_v2.2 channel (IC₅₀ = 11 μM), as well as the rat L-type Ca_v1.2, human-ether-a-go-go (hERG/K_v11.1) potassium, and human voltage-gated sodium (Na_v) channel Na_v1.5 (IC₅₀s = 32, 7.8, and 100 μM, respectively). Z944 (30 mg/kg) reduces the seizure duration and the amount of time rats spend in seizures in a model of absence epilepsy. It delays seizure progression in amygdala-kindled rats but does not inhibit seizures in fully kindled rats.

• 化学的特性

  White Solid

• 使用

  As N-Piperidinyl acetamide derivatives, N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide can be used as calcium channel blockers and their use in the treatment of obesity.

N-((1-(2-(TERT-ブチルアミノ)-2-オキソエチル)ピペリジン-4-イル)メチル)-3-クロロ-5-フルオロベンズアミド 生産企業

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N-((1-(2-(TERT-ブチルアミノ)-2-オキソエチル)ピペリジン-4-イル)メチル)-3-クロロ-5-フルオロベンズアミド スペクトルデータ(¹HNMR)