N-(1,3-ベンゾジオキソール-5-イルメチル)-2,6-ジクロロベンズアミド

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H301：飲み込むと有毒

  H400：水生生物に強い毒性

• 注意書き

  P273：環境への放出を避けること。

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

N-(1,3-ベンゾジオキソール-5-イルメチル)-2,6-ジクロロベンズアミド 価格

N-(1,3-ベンゾジオキソール-5-イルメチル)-2,6-ジクロロベンズアミド 化学特性,用途語,生産方法

• 使用

  Alda-1 has been used as an aldehyde dehydrogenase 2 (ALDH2) agonist:
  
  • to study its cryoprotective effects on H₂O₂-induced Achilles tendinopathy in mice Achilles tenocytes
  • to study its protective effects against alcohol-derived DNA damage in ALDH2 knock out mice
  • to study its effects on cutaneous wound healing in mice
  
  

• Biochem/physiol Actions

  Alda-1 is an ALDH2 agonist; cell-permeable activator of both the wild-type ALDH2*1 and the asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2. ALDH2 is the oxidative enzyme, which removes the ethanol metabolite acetaldehyde and other aliphatic aldehydes. Also. ALDH2 is involved in bioconversion of vasodilator nitroglycerin to nitric oxide. Alda-1 increases acetaldehyde oxidation by ALDH2*1 (wild type) and ALDH2*2 9 Asian variant) approximately 1.5- and 6-fold, respectively. It appears that Alda-1 stimulates acetaldehyde oxidation by ALDH2 by improving NAD binding, but does not improve the nitroglycerin binding affinity of the Asian variant.

N-(1,3-ベンゾジオキソール-5-イルメチル)-2,6-ジクロロベンズアミド 生産企業

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N-(1,3-ベンゾジオキソール-5-イルメチル)-2,6-ジクロロベンズアミド スペクトルデータ(¹HNMR)