3'-クロロプロピオフェノン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P271：屋外または換気の良い場所でのみ使用すること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

3'-クロロプロピオフェノン 価格

MSDS Information

• 1-(3-Chlorophenyl)-1-propanone

3'-クロロプロピオフェノン 化学特性,用途語,生産方法

• 外観

  白色～微褐色の結晶又は結晶性粉末

• 用途

  有機合成原料。

• 説明

  Influence of solvents and temperature on the yield and enantioselectivity of the phenylation of 3′-chloropropiophenone has been investigated.

• 化学的特性

  WHITE TO LIGHT YELLOW CRYSTALLINE SOLID

• 使用

  3'-Chloropropiophenone is a reagent used in the vinylation, alkylation and dienylation of ketones. It is also used in the preparation of thizaine derivatives that show antibacterial activity.

• 主な応用

  3′-Chloropropiophenone can be used as a reactant to synthesize:
  (S)-3-chloro-1-phenylpropanol via bio-catalyzed asymmetric reduction method.
  1-(3-Chlorophenyl)-1-phenyl-1-propanol by phenylation with diphenylzinc in the presence of dihydroxy bis(sulfonamide) ligand.
  (S)-Dapoxetine, a selective serotonin reuptake inhibitor.

• 製造方法

  4.86 g (0.2 mol) of magnesium turnings, 30 ml of dry diethyl ether and a grain of iodine are placed in a one liter three-necked round-bottomed flask equipped with a condenser, a calcium chloride drying tube, a pressure equalizing funnel and a magnetic stirrer; the flask is purged with nitrogen, and 21.8 g (0.2 mol) of ethyl bromide in 30 ml of dry diethyl ether are then added. The mixture is then heated under reflux for one hour and left to cool. At ambient temperature, 16.51 g (0.12 mol) of 3-chlorobenzonitrile in 70 ml of dry diethyl ether are then added. A copious precipitate forms. The mixture is stirred overnight at ambient temperture and then cooled in an ice bath and hydrolysed by slowly adding 50 ml of water and then about 100 ml of 6N hydrochloric acid until the pH is acid. The mixture is stirred for one and a half hours and then extracted with ethyl acetate. The organic extract is then washed twice with water, dried and concentrated on a rotary evaporator. This gives 26 g of an orange oil, which is concentrated in vacuo to give about 18.2 g of ochre crystals of 3'-chloropropiophenone melting at about 40° C.
  Literature source US04690931

3'-クロロプロピオフェノン 上流と下流の製品情報

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3'-クロロプロピオフェノン スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、MS、Raman)

34841-35-5, 3'-クロロプロピオフェノン キーワード