ダイゼイン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P332+P313：皮膚刺激が生じた場合：医師の診断/手当てを受けるこ と。

  P337+P313：眼の刺激が続く場合：医師の診断/手当てを受けること。

ダイゼイン 価格

MSDS Information

• 4',7-Dihydroxyisoflavone

ダイゼイン 化学特性,用途語,生産方法

• 外観

  白色～ほとんど白色粉末～結晶

• 定義

  本品は、次の化学式で表される有機化合物である。

• 解説

  ダイゼイン，イソフラボン類の一つ．マメ科Pueraria thunbergiana Benth.の根に含まれ，またGlycine hispida L.の種子では配糖体ダイジンとして存在する植物エストロゲンの一種．マメ科の植物に存在し、大豆や豆腐などの食品にも含まれる。体内で雌性ホルモンと似たはたらきをするファイトエストロゲンの一つとして知られる。無色の柱状晶．融点315～320 ℃(300 ℃ より黒変する)．λmax 250 nm(log ε 4.44)．水に不溶，アルコール類，アセトンに可溶．アルカリに溶けて，溶液は紫外線下で蛍光を発する．塩化鉄(Ⅲ)溶液で呈色しない．

• 化粧品の成分用途

  皮膚コンディショニング剤

• 説明

  Daidzein mainly comes from leguminous plants, the seeds of soybean (dadou), red clover grass, or all Pueraria roots. Its medicinal value was first recorded in Shen Nong Ben Cao Jing 2838 BC.?Daidzein, one of the main soy isoflavones, is also the main component of radix puerariae (Gegen) which is the dry root of kudzu leguminous plants. Radix puerariae can reduce fever, produce saliva, and relieve diarrhea. Its chemical composition is complicated, including puerarin, xyloside, soy flavonoids, soybean flavonoid glycosides, beta-sitosterol, daidzin, daidzein. The main effective components are puerarin and daidzein

• 化学的特性

  Off-White Crystalline Solid

• 物理的性質

  Appearance: pale-yellow prismatic crystal. Melting point: 315–323?°C. Solubility: soluble in ethanol and ether

• 来歴

  Daidzein is a kind of isoflavone compound, which was first synthetized by researchers in China. It has been widely used in drugs, food supplements, and cosmetics. Because of two phenolic hydroxyl structures, Daidzein has poor water solubility, poor liposolubility, and strong first-pass effect, leading to the low bioavailability of oral absorption, which limits its widely clinical usage.
  Ipriflavone is a kind of isoflavone modified from Daidzein, which has been used for the treatment of osteoporosis in Japan and some European countries. The effects of a series of amino alkoxy derivatives of ipriflavones on inhibiting the bone absorption were evaluated. The researchers found that 7-amino alkoxy derivative works best. When Daidzein was alkylated or acylated at 7-hydroxyl selectively, the stability was increased, and thus the proliferation of MCF-7 cell was inhibited.

• 使用

  Inactive analog of Genistein (Cat. #G350000). Blocks the G1 phase of the cell cycle in Swiss 3T3 cells by inhibiting casein kinase II activity1. Daidzein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv max:250 nm (log e 4.44)

• 適応症

  Daidzein is mainly used for the treatment of hypertension, coronary heart disease, cerebral thrombosis, and vertigo and aids in the treatment of sudden deafness. It can also treat women with menopause syndrome.

• 定義

  ChEBI: A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by an additional hydroxy group at position 4'.

• 一般的な説明

  Daidzein is an endocrine-active estrogenic isoflavone. This phytoestrogen is capable to bind to estrogen to exert estrogenic effects in vivo. It can naturally be found in soybean seed and flour.

• 生物活性

  Analog of the phytoestrogen genistein (5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one ). Blocks G 1 phase cell cycle progression and is an agonist at estrogen receptors.

• 臨床応用

  Daidzein can expand the coronary artery, femoral artery, and cerebral artery, increase cerebral blood flow and limb blood circulation, reduce blood viscosity and vascular resistance, decrease myocardial oxygen consumption, improve heartfunction, increase the microcirculation and blood flow to the tip, lower the blood pressure, and adjust the heart rhythm. Daidzein can be used for the treatment of hypertension, coronary heart disease, angina pectoris, myocardial infarction, cerebral thrombosis, dizziness, and sudden deafness. It can also be used for women’s menopause syndrome.

ダイゼイン 上流と下流の製品情報

ダイゼイン 生産企業

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ダイゼイン スペクトルデータ(¹HNMR)

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