ポリ塩化ビフェニル

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H373：長期にわたる、または反復暴露により臓器の障 害のおそれ

  H410：長期的影響により水生生物に非常に強い毒性

• 注意書き

  P260：粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。

  P273：環境への放出を避けること。

  P314：気分が悪い時は、医師の診断/手当てを受けること。

  P391：漏出物を回収すること。

  P501：内容物/容器を．．．に廃棄すること。

ポリ塩化ビフェニル 化学特性,用途語,生産方法

• 解説

  ビフェニルの塩素置換によって得られる有機化合物．化学物質の規制や環境汚染などに関する法律用語では，ポリ塩化ビフェニルという．塩素原子数や置換位置の異なるものの総称．PCBと略記される．熱に対して安定で，電気絶縁性が高い．かつて熱媒体，トランス油，コンデンサー，ノーカーボン紙に用いられた．人体に対する毒性が高く，症状は皮膚への色素沈着，皮膚障害，消化器障害，肝障害などであるが，PCBは脂肪組織に蓄積し，症状は長期にわたる．わが国では1972年に製造が中止された．

• 説明

  Polychlorinated biphenyls (PCBs) are one of the most widely studied environmental contaminants, and many studies in animals and human populations have been performed to assess the potential carcinogenicity of PCBs. PCBs are mixtures of up to 209 individual chlorinated compounds (known as congeners or chlorinated hydrocarbons), which are no longer produced in the United States, but are still found in the environment. Exposure to PCBs includes acne-like skin conditions in adults and neurobehavioral and immune alterations in children. PCBs are carcinogenic to animals, and they have been found in at least 500 of the 1598 National Priorities List sites identified by the US Environmental Protection Agency (EPA). PCBs (US trade name Aroclor) have no known natural sources, are either oily liquids or solids that are colorless to light yellow, and can exist as a vapor in air. PCBs typically do not exhibit any smell or taste.
  The US Toxic Substances Control Act (TSCA) was enacted by the US Congress to control the distribution, use, and disposal of harmful chemicals, including PCBs. PCBs have been demonstrated to cause a variety of adverse health effects. Studies in humans provide supportive evidence for potential carcinogenic and noncarcinogenic effects of PCBs, and based on the weight of the data, it is suggested that PCBs are probable human carcinogens.

• 使用

  Before 1974, PCBs were used in the United States for both enclosed applications, such as transformers, capacitors, and heat transfer and hydraulic fluids, and open applications, such as inks, flame retardants, adhesives, carbonless duplicating paper, paints, plasticizers, wire insulators, metal coatings, and pesticide extenders (IARC 1978, ATSDR 2000). After 1974, all uses of PCBs were limited to enclosed applications (transformers and capacitors), and after January 1979, no PCBs were used in the manufacturing of transformers or capacitors. The only remaining permitted uses of PCBs are as a mounting medium in microscopy, as an immersion oil in low-fluorescence microscopy, as an optical liquid, and for other research and development purposes (ATSDR 2000).

• 調製方法

  PCBs are synthesized by the chlorination of biphenyl and the resulting products are designated according to their percent (by weight) chlorine content (2). For example, Aroclors 1221, 1242, and 1260 contain 21, 42, and 60 wt% chlorine. The commercial Aroclors were produced by the Monsanto Chemical Corp. and similar PCB mixtures were manufactured worldwide by other chemical companies. Over 600 million kg of commercial PCBs were produced in the United States and the estimated worldwide production is approximately double this quantity (Table 1). Properties of the commercial PCBs varied from highly fluid liquids (Aroclor 1221) to viscous liquids or solids. All of these preparations contained a complex mixture of isomers and congeners and as the degree of chlorination increased there was a corresponding increase in the relative concentrations of the more highly chlorinated congeners. There are 209 possible PCBs and the properties of these commercial mixtures and the individual PCBs have been extensively investigated. More recent studies indicate that the commercial PCBs contained 132 different compounds (18).

• 安全性プロファイル

  Confirmed carcinogen with carcinogenic and tumorigenic data. Moderately toxic by ingestion. Some are poisons by other routes. Experimental reproductive effects. Like the chlorinated naphthalenes, the chlorinated diphenyls have two distinct actions on the body, namely, a skin effect and a toxic action on the liver. This hepato- toxic action of the chlorinated diphenyls appears to be increased if there is exposure to carbon tetrachloride at the same time. The higher the chlorine content of the diphenyl compound, the more toxic it is liable to be. Oxides of chlorinated diphenyls are more toxic than the unoxidmed materials. In persons who have suffered systemic intoxication, the usual signs and symptoms are nausea, vomiting, loss of weight, jaundice, edema, and abdominal pain. If the liver damage has been severe the patient may pass into a coma and die. Combustible when exposed to heat or flame, When heated to decomposition they emit highly toxic fumes of Cl-. See also specific compounds.

• 職業ばく露

  Several studies have reported relatively high levels of PCBs in the serum or adipose tissues of occupationallyexposed individuals, e.g.,>3000 ppb in the serum (57 58). Not surprisingly, after these exposures were terminated, the PCB serum concentrations tended to decrease (59 61). Chloracne and related skin problems have been observed in several groups of workers and it was suggested that the air concentrations of commercial PCBs > 0.2 mg/m3 were associated with this effect (62). It was also reported that after occupational exposure to PCBs was terminated there was a gradual decrease in the severity and number of dermatological problems in the exposed workers, and this paralleled a decrease in their serum levels of PCBs (61). The effects of occupational exposure to PCBs on the concentrations of several serum clinical, chemical, and hematological parameters have been reported (58). Mildly elevated SGOT and γ -glutamyl transpeptidase (GGTP) suggest some liver damage and induction of hepatic monooxygenase enzymes; these results are similar to those observed in animal studies. In one study, it was reported that as PCB serum levels decreased over time the GGTP serum levels also decreased to normal values.

• 発がん性

  Polychlorinated biphenyls (PCBs) are reasonably anticipated to be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals. Not all PCB mixtures caused tumors in experimental animals.

• 環境運命予測

  Before being banned and before the US Clean Water Act regulated wastewater discharges, PCBs could be found, often at high levels, in wastewaters from industries handling PCB equipment. These wastewaters either were discharged directly to surface waters or sent to municipal sewage treatment plants. Urban industrial areas are more likely to have higher PCB contamination than rural areas. While not highly volatile, PCBs, especially the less chlorinated ones, will partition into the air. Atmospheric transport is the most important mechanism for dispersion of PCBs.
  Those PCBs with a high degree of chlorination are much more persistent in the environment than those with lower degrees of chlorination because they are more resistant to metabolism. Microbial metabolism is the most important mechanism for the removal of persistent organic pollutants as the PCBs from the environment. Anaerobic dehalogenation of the highly chlorinated PCBs in aquatic sediments is a major mechanism for their elimination by generating lower chlorinated congeners that are more readily metabolized by aerobic enzymes. As a consequence, the environmental levels of PCBs are slowly decreasing with time.

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