3β-ヒドロキシコレスタ-5-エン-7-オン

3β-ヒドロキシコレスタ-5-エン-7-オン 価格

3β-ヒドロキシコレスタ-5-エン-7-オン 化学特性,用途語,生産方法

• 説明

  7-keto Cholesterol is a bioactive sterol and a major oxysterol component of oxidized LDL. It is produced by oxidation of cholesterol via ethanol-mediated lipid peroxidation or photodamage as well as oxidation of 7-dehydro cholesterol by the cytochrome P450 (CYP) isoform CYP7A1. 7-keto Cholesterol inhibits CYP7A1 (IC₅₀ = ~1 μM). It induces activation and chemotaxis of retinal microglia as well as polarization to a pro-inflammatory state via NLRP3 inflammasome activation in vitro. Intraocular implantation of 7-keto cholesterol coated wafers increases ocular levels of VEGF, IL-1β, and GRO/KC, macrophage infiltration, and neovascularization in rat eye. Levels of 7-keto cholesterol in lipid deposits are increased in a variety of chronic diseases, including atherosclerosis, Alzheimer''s disease, and age-related macular degeneration.

• 化学的特性

  Off-White Solid

• 使用

  A metabolite of Cholesterol

• 定義

  ChEBI: A cholestanoid that consists of cholesterol bearing an oxo substituent at position 7.

• 一般的な説明

  7-ketocholesterol is a major oxidation product of cholesterol.

• 安全性プロファイル

  Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits acrid smoke and irritating fumes

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3β-ヒドロキシコレスタ-5-エン-7-オン 生産企業

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3β-ヒドロキシコレスタ-5-エン-7-オン スペクトルデータ(¹HNMR、IR1、IR2、MS)

566-28-9, 3β-ヒドロキシコレスタ-5-エン-7-オン キーワード