2-ヒドロキシグルタル酸二ナトリウム塩, CONTAINS UP TO 10% METHANOL

2-ヒドロキシグルタル酸二ナトリウム塩, CONTAINS UP TO 10% METHANOL 価格

2-ヒドロキシグルタル酸二ナトリウム塩, CONTAINS UP TO 10% METHANOL 化学特性,用途語,生産方法

• 説明

  α-Hydroxyglutaric acid (2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases, and mutations in these enzymes lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased levels of L-2-hydroxyglutaric acid . 2-HG can also be metabolized from isocitrate by mutated forms of isocitrate dehydrogenase 1 (IDH1) and IDH2. 2-HG is structurally similar to α-ketoglutarate, the product of wild-type isocitrate dehydrogenases, and competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone lysine demethylases and DNA hydroxylases.

• 化学的特性

  White to Off-White Solid

• 使用

  2-Hydroxyglutaric acid is a potential inhibitor of glutamate carboxypeptidase.

2-ヒドロキシグルタル酸二ナトリウム塩, CONTAINS UP TO 10% METHANOL 生産企業

Global(43)Suppliers

2-ヒドロキシグルタル酸二ナトリウム塩, CONTAINS UP TO 10% METHANOL スペクトルデータ(MS)