(1S,14R)-20,25-ジメトキシ-15,30-ジメチル-7,23-ジオキサ-15,30-ジアザヘプタシクロ[22.6.2.23,6.18,12.114,18.027,31.022,33]ヘキサトリアコンタ-3,5,8(34),9,11,18(33),19,21,24,26,31,35-ドデカエン-9,21-ジオール

(1S,14R)-20,25-ジメトキシ-15,30-ジメチル-7,23-ジオキサ-15,30-ジアザヘプタシクロ[22.6.2.23,6.18,12.114,18.027,31.022,33]ヘキサトリアコンタ-3,5,8(34),9,11,18(33),19,21,24,26,31,35-ドデカエン-9,21-ジオール 化学特性,用途語,生産方法

• 説明

  A bisbenzylisoquinoline alkaloid present in Berberis tachonoskyana, the base may be recrystallized from C6H6 when it forms colourless needles containing solvent, m.p. 135-6°C (dec.). It is dextrorotatory with [α] ⁹ _D + 98.5° (MeOH). Two methoxyl groups, two phenolic hydroxyl groups and two methylimino groups are present in the molecule. The O,O-dimethyl ether is identical with iso_x0002_tetrandrine and the corresponding diethyl ether crystallizes as small granules with m.p. 196-8°C; [α] ²⁵ _D+ 140°. The structure given has been determined primarily from the mass spectrum.

• 参考文献

  Tomita, Kugo.,J. Pharm. Soc., Japan, 79,317 (1959)
  Kugo., ibid, 79,322 (1959)
  Mass spectrum: Dejongh, Shrader, Cava.,J. Amer. Chem. Soc., 88, 1052 (1966)