SB-223412

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H301：飲み込むと有毒

• 注意書き

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

SB-223412 価格

SB-223412 化学特性,用途語,生産方法

• 説明

  Talnetant is an antagonist of the neurokinin-3 (NK₃) receptor (K_i = 1 nM). It is selective for NK₃ over NK₁ and NK₂ receptors (K_is = 144 and >100,000 nM, respectively, in CHO cells expressing recombinant human receptors). Talnetant inhibits calcium mobilization induced by neurokinin B in HEK293 cells expressing human NK₃ receptors (IC₅₀ = 16.6 nM). It inhibits contractions induced by the NK₃ receptor agonist senktide in isolated rabbit iris sphincter muscle (pD₂ = 9.1). Talnetant (5-20 mg/kg) reduces senktide-induced head shakes and tail whips in mice. It also inhibits senktide-induced wet-dog shakes, increases extracellular dopamine and norepinephrine in the medial prefrontal cortex, and attenuates haloperidol-induced increases in nucleus accumbens dopamine levels in guinea pigs.

SB-223412 上流と下流の製品情報

SB-223412 生産企業

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