アシアチコシド

アシアチコシド 価格

MSDS Information

• [6-[[3,4-Dihydroxy-6-(hydroxymethyl)-5-(3,4,5-trihydroxy-6-methyl-oxan-2-yl)oxy-oxan-2-yl]oxymethyl]-3,4,5-trihydroxy-oxan-2-yl] (1S,2R,4aS,6aS,6bR,9S,10R,11R,12aS,14bR)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate

アシアチコシド 化学特性,用途語,生産方法

• 定義

  本品は、アシアチン酸(*)の糖誘導体で、次の化学式で表される。
  参照表示名称：アシアチン酸

• 化粧品の成分用途

  皮膚コンディショニング剤、酸化防止剤

• 効能

  血管保護薬, 創傷治癒薬

• 説明

  Asiaticoside is the main saponin constituent of C. asiatica, a plant long used in the Ayurvedic system of medicine to treat a variety of ailments including dermatitis, diabetes, cough, cataract, hypertension, as well as for wound healing and improving memory. In various wound healing models, topical application (0.2-0.4%), injection (1 mg), or ingestion (1 mg/kg) of asiaticoside has been shown to increase hydroxyproline content, improve tensile strength, increase collagen synthesis and remodeling of the collagen matrix, promote epithelialization, stimulate glycosaminoglycan synthesis, and elevate antioxidant levels.

• 化学的特性

  White powder

• 使用

  Asiatic Acid is a terpenoid saponin component isolated from Centella asiatica with antioxidant and anti-inflammatory activities. Asiaticoside has been shown to possess strong wound-healing properties and reduces scar formation.

• 生物活性

  Asiaticoside, a triterpenoid compound from Centella asiatica, has been shown to have anti-inflammatory, anti-renal fibrosis and tissue repair promoting effects. Asiaticoside has been shown through ex vivo and in vivo studies to reduce blood urea nitrogen (BUN) and serum creatinine (Scr) levels in a renal ischemia-reperfusion injury (IRI) model ^[1]. Meanwhile, Asiaticoside decreased the secretion of IL-6, IL-1β, and TNF-α, but increased the secretion of IL-10 using a dose-dependent manner. Treatment of Raw264.7 cells with lipopolysaccharide (LPS) induced an inflammatory response, but the LPS-induced effect was attenuated by the administration of asiaticoside. In addition, asiaticoside significantly inhibits LPS-induced expression of inducible nitric oxide synthase (iNOS) and promotes expression of the polarisation marker protein arginase 1. It is also a potential candidate for use as a dental wound healing agent with a maximum tolerated concentration of 0.25 mg/ml, and its mechanism of action may be related to increased Col1A1 gene expression ^[2].

• 安全性プロファイル

  Questionable carcinogen withexperimental tumorigenic data. When heated todecomposition it emits acrid smoke and fumes. Promoteshealing of wounds.

アシアチコシド 上流と下流の製品情報

アシアチコシド 生産企業

Global(494)Suppliers

アシアチコシド スペクトルデータ(¹HNMR)

16830-15-2, アシアチコシド キーワード