6,7,8,9-テトラヒドロ-2,12-ジメトキシ-7-メチル-6-(2-フェニルエチル)-5H-ジベンゾ[d,f]アゾニン-1-オール・塩酸塩

6,7,8,9-テトラヒドロ-2,12-ジメトキシ-7-メチル-6-(2-フェニルエチル)-5H-ジベンゾ[d,f]アゾニン-1-オール・塩酸塩 化学特性,用途語,生産方法

• Originator

  Asocainol,ZYF Pharm

• Manufacturing Process

  A solution of a Grignard reagent is prepared from 5.5 g (0.23 mol) activated magnesium turnings and 41.5 g (0.24 mol) phenethyl bromide in 200 ml anhydrous diethyl ether. To this is added dropwise, at 35-40°C, a solution of 31.5 g (0.1 mol) thebaine in 0.4 liters dry benzene. After heating under reflux for 2 hours, the reaction mixture is decomposed with a solution of 48 g ammonium chloride in 200 ml water. The usual working up, after conversion of the base into the hydrochloride by means of hydrogen chloride in ethyl acetate, gives 7.3 g (21% of theory) (+/-)-2,12-dimethoxy-1-hydroxy-7- methyl-6-phenethyl-5,6,8,9-tetrahydro-7H-dibenz[d,f]azonine hydrochloride, melting point 227.6°C, after recrystallization from propan-2-ol.

• Therapeutic Function

  Antiarrhythmic

6,7,8,9-テトラヒドロ-2,12-ジメトキシ-7-メチル-6-(2-フェニルエチル)-5H-ジベンゾ[d,f]アゾニン-1-オール・塩酸塩 上流と下流の製品情報

6,7,8,9-テトラヒドロ-2,12-ジメトキシ-7-メチル-6-(2-フェニルエチル)-5H-ジベンゾ[d,f]アゾニン-1-オール・塩酸塩 生産企業

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