合成非晶質シリカ

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H330：吸入すると生命に危険

• 注意書き

  P260：粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。

  P271：屋外または換気の良い場所でのみ使用すること。

  P284：呼吸用保護具を着用すること。

  P304+P340：吸入した場合：空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。

  P310：ただちに医師に連絡すること。

  P320：特別な治療が緊急に必要である（このラベ ルの．．．を見よ）。

  P403+P233：換気の良い場所で保管すること。容器を密閉 しておくこと。

  P405：施錠して保管すること。

  P501：内容物/容器を．．．に廃棄すること。

合成非晶質シリカ 化学特性,用途語,生産方法

• 定義

  本品は、シリカ(*)をジメチルシリル化したものである。参照表示名称：シリカ

• 化粧品の成分用途

  非活性剤系分散剤、非水系増粘剤、滑沢剤、抗ケーキング剤、増量剤

• 化学的特性

  Hydrophobic colloidal silica occurs as a light, fine, white or almost white amorphous powder, not wettable by water.

• 調製方法

  Hydrophobic colloidal silica is prepared by the flame hydrolysis of chlorosilanes, such as silicon tetrachloride, at 1800°C using a hydrogen–oxygen flame. It is rapidly cooled to create an amorphous productand immediately treated with dichlorodimethyl silane in a fluid bed reactor. The resulting surface is covered with dimethylsilyl groups. Aerosil R972 is manufactured by modifying the surface of Aerosil 130 and thus has the same primary particle size and surface area, but the density of silanol groups is reduced from approximately 2.0 SiOH/nm2 to 0.75 SiOH/nm2.

• 応用例（製薬）

  large specific surface area, which provide desirable flow characteristics in dry powders used in tableting and capsule filling. The hydrophobic grades absorb less moistureand may offer an advantage in moisture-sensitive formulations.
  Hydrophobic colloidal silica is also used to thixotropically control viscosity, to thicken and stabilize emulsions, or as a suspending agent in gels and semisolid preparations. Hydrophobic colloidal silica has a less pronounced effect on solution viscosity but can thicken and stabilize the oil phase of a water–oil emulsion. With other ingredients of similar refractive index, transparent gels may be formed. Generally, the uses and ranges of hydrophobic colloidal silica are similar to the concentrations used of the standard hydrophilic colloidal silicon dioxide.

• 安全性

  The safety profile of hydrophobic colloidal silica is the same as for the hydrophilic silica types, as the modified silica surface does not significantly alter the toxicological properties.
  LD50 (rat, IV): 0.015 g/kg

• 貯蔵

  Hydrophobic colloidal silica should be stored in a well-closed container. It will not absorb moisture but may still absorb volatile substances owing to its high surface area.

• 不和合性

  Use of the hydrophobic colloidal silica Aerosil R972 reduces the strength of starch-based tablets.

• 規制状況(Regulatory Status)

  Approved for use in pharmaceuticals in Europe. Approved by FDA and Europe for food contact articles. Included in nonparenteral medicines (oral tablets; rectal suppositories) licensed in the UK.

合成非晶質シリカ 上流と下流の製品情報

合成非晶質シリカ 生産企業

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68611-44-9, 合成非晶質シリカ キーワード