クロフェンビンホス

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H300：飲み込むと生命に危険

  H311：皮膚に接触すると有毒

  H410：長期的影響により水生生物に非常に強い毒性

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P273：環境への放出を避けること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

クロフェンビンホス 価格

クロフェンビンホス 化学特性,用途語,生産方法

• 効能

  殺虫薬, アセチルコリンエステラーゼ阻害薬

• 化学的特性

  Chlorfenvinphos is a nonflammable, yellow or amber liquid with a mild odor.

• 使用

  Insecticide; acaricide.

• 製造方法

  Chlorfenvinphos is synthesized by the Perkow reaction of triethyl phosphite with 2,4-α,α-tetrachloroacetophenone. Technical product is an E/Z isomer mixture with an E : Z ratio of 1 : 8–9 and an amber liquid, bp 167–170 ?C/0.5 mm Hg, vp 1 mPa (25 ?C), sparingly soluble in water (145 mg/L), and miscible with most common organic solvents such as acetone and aromatic hydrocarbons. Log Kow = 3.85. It is hydrolyzed slowly in slightly alkaline aqueous solutions and rapidly in strongly alkaline solutions; DT₅₀ values are >700 h (pH 1.1, 38 ?C), >400 h (pH 9.1, 38 ?C), and 1.28 h (pH 13, 20 ?C).

• 一般的な説明

  Amber-colored liquid with a mild chemical odor. Used for control of ticks, flies, lice, and mites on cattle and for blowfly, lice, ked, and itchmite on sheep. Controls fleas and mites on dogs; not used on cats. Applied on organic wastes and breeding places of fly larvae. Also used as a foliage insecticide for potatoes, rice, maize, and sugar cane. Used to control soil insects.

• 空気と水の反応

  Slightly soluble in water.

• 反応プロフィール

  Organophosphates, such as Chlorfenvinfos, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

• 危険性

  A cholinesterase inhibitor.

• 健康ハザード

  Acute: cholinesterase inhibitor which affects central nervous system. Severe illness or death possible. Convulsions or coma and death.

• 火災危険

  (Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) Chlorfenvinfos may burn but does not ignite readily. Container may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases. Avoid iron, steel, and brass. Stable when stored in glass or polyethylene lined containers. Avoid alkaline aqueous solutions.

• 安全性プロファイル

  Poison by ingestion, skin contact, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by skin contact: unspecified blood system effects. Mutation data reported. A cholinesterase inhibitor. An insecticide. See also PARATHION. When heated to decomposition it emits very toxic fumes of Cland POx.

• 職業ばく露

  Used as a soil insecticide for root maggots, rootworms, and cutworms. Those engaged in the production, formulation, and application of this insecticide.

• 環境運命予測

  The mechanism of toxicity of chlorfenvinphos is related to its binding and inhibition of the serine hydrolase AChE. In the nervous system, AChE hydrolyzes the neurotransmitter acetylcholine, thereby terminating its synaptic action. AChE inhibition increases the availability of acetylcholine at the neural synapse, leading to cholinergic overstimulation, autonomic and neuromuscular dysfunction, and at higher levels, resulting in coma and death. Major metabolites of chlorfenvinphos do not inhibit ChE. Chlorfenvinphos inhibits butyrylcholinesterase which may function as a molecular scavenger for anti-ChE compounds in the blood or substitute for AChE where it is low.
  The stress responses to acute exposure of chlorfenvinphos are evidenced in rats by rapidly increased plasma corticosterone concentrations and a prolonged reduced sensitivity to psychostimulants such as amphetamine. These effects were attributed to the hyperactivity of the cholinergic system from ChE inhibition, leading to persistent alterations of the brain cholinergic–dopaminergic balance.
  Other potentially more sensitive non-ChE targets that may influence the overall toxicity of chlorfenvinphos include lipid metabolism, oxidative stress, aromatic amino acid transferases, and cytotoxicity. Chlorfenvinphos may act via central noradrenergic mechanisms to induce hypotension by accelerating the noradrenaline turnover in the brain. Chlorfenvinphos induces hepatic CYPs.

• 輸送方法

  UN3018 Organophosphorus pesticides, liquid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

• 不和合性

  Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Strong oxidizers may cause release of toxic phosphorus oxides. Organophosphates, in the presence of strong reducing agents such as hydrides, may form highly toxic and flammable phosphine gas. Keep away from alkaline materials. May be corrosive to metals in the presence of moisture.

• 廃棄物の処理

  Destruction by alkali hydrolysis or incineration. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

470-90-6, クロフェンビンホス キーワード