クロロチアジド

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H317：アレルギー性皮膚反応を起こすおそれ

  H334：吸入するとアレルギー、喘息または、呼吸困難 を起こすおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P272：汚染された作業衣は作業場から出さないこと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P284：呼吸用保護具を着用すること。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

クロロチアジド 価格

MSDS Information

• Chlorothiazide

クロロチアジド 化学特性,用途語,生産方法

• 解説

  サイアザイド(thiazide) 利尿剤の一つ。スルファニルベンゾサイアダイアジン系で、経口的投与によって有効に作用。

• 効能

  血圧降下薬, 利尿薬, Na+-Cl-再吸収阻害薬

• 説明

  Chlorothiazide is a first-in-class thiazide diuretic initially discovered from its ability to inhibit carbonic anhydrase in vitro. As an antihypertensive agent, this thiazide increases renal excretion of sodium, potassium, chloride, and bicarbonate ions by inhibiting tubular reabsorptive mechanisms.

• 化学的特性

  Off-White Solid

• 使用

  Chlorthiazide is a diuretic that causes the body to excrete excess fluid. This drug exhibits strong diuretic action during both acidosis and alkalosis. It is used for arterial hypertension, in edematous syndromes of various genesis, congestive effects in cardiovascular insufficiency, nephrosis and nephritis, and toxicosis. It is especially recommended for hypertonic illnesses. It lowers intraocular pressure in a number of cases.

• 定義

  ChEBI: Chlorothiazide is 4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension. It has a role as a diuretic and an antihypertensive agent.

• 一般的な説明

  Crystals; white powder.

• 空気と水の反応

  Insoluble in water.

• 反応プロフィール

  Alkaline aqueous solutions will decompose on standing or heating .

• 火災危険

  Flash point data for Chlorothiazide are not available; however, Chlorothiazide is probably combustible.

• 作用機序

  The mechanism of action of Chlorothiazide is an interference with the renal tubular mechanism of electrolyte reabsorption. The diuretic action of chlorothiazide, like other drugs of this series, is caused by reduced absorption of sodium and chloride ions by the kidneys during their simultaneous, intense excretion from the organism.

• 安全性プロファイル

  Moderately_toxic by intraperitoneal and intravenous routes. Mddly toxic by ingestion. Experimental reproductive effects. Has been implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of SOx NOx and Cl-.

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