Haptoglobin, Mixed Type, Human Plasma, CAS 9087-69-8, is a hemoglobin-binding acute-phase protein that promotes cholesterol crystallization. It is a tetramer composed of α- and β-polypeptide chains.
Haptoglobin was used to study induction of the acrosome reaction in sperm. Exposure to low temperature increases their rate of fusion with zona-free hamster oocytes.
一般的な説明
Haptoglobin is an α2-globulin found in normal plasma at a concentration of 82-236 mg/dl and accounts for 0.4-2.6% of the total plasma proteins.The monomeric form of this acute phase plasma protein is composed of four polypeptide chains: two α chains and two β chains.
Biochem/physiol Actions
Functions by binding to plasma hemoglobin (from hemolysis). The complex is removed from the circulation, by binding to CD163 receptors on macrophages, to salvage iron and prevent oxidative damage.
