PD168077マレイン酸塩

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

• 注意書き

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

PD168077マレイン酸塩 価格

PD168077マレイン酸塩 化学特性,用途語,生産方法

• 説明

  PD 168077 is a dopamine D₄ receptor agonist (K_i = 8.7 nM in CHO Pro 5 cells expressing the human receptor). It is selective for dopamine D₄ over D₂ and D₃ receptors (K_is = 3,740 and 2,810 nM, respectively), as well as α₁- and α₂-adrenergic and serotonin (5-HT) receptor subtypes 5-HT_1A and 5-HT_2A (K_is = 168, 177, 385, and 4,010 nM, respectively). PD 168077 (20 μM) induces CaMKII translocation from the dendritic shaft to postsynaptic sites on the dendritic processes of primary rat embryonic prefrontal cortex pyramidal neurons, an effect that can be blocked by the IP₃ receptor antagonist 2APB or the calcium chelator BAPTA AM . PD 168077 (50-200 ng/animal) induces penile erections in rats when injected into the paraventricular nucleus (PVN) of the hypothalamus. PD 168077 (0.2-25 mg/kg, s.c.) increases spontaneous locomotor activity and reduces grooming and rearing in rats.

• 生物活性

  A potent D 4 dopamine receptor agonist (K i = 8.7 nM) with > 400-fold selectivity over D 2 and > 300-fold selectivity versus D 3 subtypes respectively. Induces synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons. Centrally active in vivo .

PD168077マレイン酸塩 生産企業

Global(41)Suppliers