H1152二塩酸塩

H1152二塩酸塩 価格

H1152二塩酸塩 化学特性,用途語,生産方法

• 外観

  白色〜わずかにうすい黄色, 結晶〜粉末

• 溶解性

  メタノール及び水に溶ける。

• 使用上の注意

  不活性ガス封入

• 化学的特性

  White to Off-White Solid

• 使用

  ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compoud that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine

• 一般的な説明

  A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, reversible, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK; K_i = 1.6 nM). Exhibits a much weaker affinity for other serine/threonine kinases (K_i = 630 nM for PKA, 9.27 μM for PKC, and 10.1 μM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC₅₀ = 2.5 μM) in NT-2 cells. Reported to be more potent and selective than Y-27632 (Cat. Nos. 688000 and 688001). Mainly targets Aurora Kinase A, and induces polyploidization of acute megakaryocytic leukemia cells (AMKL). At 10 mM (500 μg/128 μl) solution of Rho Kinase Inhibitor (Cat. No. 555552) in H₂O is also available.

H1152二塩酸塩 生産企業

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H1152二塩酸塩 スペクトルデータ(¹HNMR)