GW-501516

GW-501516 化学特性,用途語,生産方法

• 生物活性

  GW 501516 is shown to be the most potent and selective PPARα agonists known with an EC50 of 1.1 nM against PPARα and 1000-fold selectivity over the other human subtypes, PPARα and-γ. GW 501516 exerts anti-inflammatory effects in mouse cultured proximal tubular (mProx) cells. GW 501516 inhibits palmitate- and TNFα-induced increases in MCP-1 mRNA expression in a dose-dependent manner.

• 合成

  Add Cs2CO3 (3.25 g, 10.0 mmol), followed by the chloromethylthiazole (2.60 g) to a stirred solution of 4-mercapto-2-methylphenol (1.40 g) in CH3CN (80 mL). Stir the reaction mixture at room temperature for 4 hours. Add Cs2CO3 (4.89 g, 15.0 mmol), followed by methyl bromoacetate (1.23 mL, 13.0 mmol) to the mixture. Stir the reaction mixture at room temperature for another 5 hours. Pour the mixture into water. Extract the mixture with EtOAc (3 x 100 mL). Combine the organic layers. Wash the organic layers with brine. Dry the organic layers (Na2SO4). Concentrate the organic layers. Purify the residue by column chromatography on silica gel with hexane/ ethyl acetate (5:1). 1H NMR (CDCl3) δ7.97 (d, 2H, J= 8.4 Hz), 7.65 (d, 2H, J= 8.4 Hz), 7.21 (d, 1H, J= 2.4 Hz), 7.13 (dd, 1H, J= 8.4, 2.4 Hz), 6.58 (d, 1H, J= 8.4 Hz), 4.63 (s, 2H), 4.11 (s, 2H), 3.78 (s, 3H), 2.24 (s, 3H), 2.20 (s, 3H). 13C NMR (CDCl3) δ169.2, 163.0, 156.3, 151.3, 136.8, 136.1, 132.1, 131.2 (q, J= 32 Hz), 130.6, 128.4, 126.3, 125.8 (q, J= 4 Hz), 125.3, 122.1, 111.4, 65.4, 52.2, 32.4, 16.1, 14.8. 19F NMR (CDCl3) δ115.5 (s).
  
  Fig. The synthetic step 1 of GW-501516

GW-501516 生産企業

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