5,6,7,4'-テトラヒドロキシフラボン

5,6,7,4'-テトラヒドロキシフラボン 価格

5,6,7,4'-テトラヒドロキシフラボン 化学特性,用途語,生産方法

• 外観

  うすい黄色～くすんだ黄色～暗い緑色粉末～結晶

• 説明

  Scutellarein is a flavone that has been isolated from S. baicalensis and has antioxidant, enzyme inhibitory, anti-inflammatory, and antiproliferative biological activities. It has antioxidant activity in a total reactive antioxidant potential (TRAP) assay when used at a concentration of 1 μg/ml. Scutellarein inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the severe acute respiratory syndrome (SARS) coronavirus helicase nsP13 (IC₅₀s = 12 and 0.86 μM, respectively). It decreases nitric oxide (NO) release and mRNA expression of inducible NO synthase (iNOS) and TNF-α induced by LPS in RAW 264.7 macrophages when used at a concentration of 50 μM. In vivo, scutellarein (0.5 μg/g) decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model.

• 化学的特性

  Yellow solid

• 使用

  Scutellarein is a flavonoid that can be found in Scutellaria lateriflora. Scutellarein is a hydrolysis product of Scutellarein (S201900), its glucuronide conjugated analogue.

• 定義

  ChEBI: Flavone substituted with hydroxy groups at C-4', -5, -6 and -7.

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