グルテチミド
化学名:グルテチミド
CAS番号.77-21-4
英語名:DL-Glutethimide
CBNumberCB6399670
MFC13H15NO2
MW217.26
MOL File77-21-4.mol
别名
(3S)-3α-フェニル-3-エチルピペリジン-2,6-ジオン
3-フェニル-3-エチルピペリジン-2,6-ジオン
3-エチル-3-フェニル-2,6-ピペリジンジオン
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グルテチミド物理性質
| 融点 | 84°C |
| 沸点 | 357.82°C (rough estimate) |
| 比重(密度) | 1.0960 (rough estimate) |
| 屈折率 | 1.5300 (estimate) |
| 闪点 | 9℃ |
| 貯蔵温度 | -20°C |
| 溶解性 | Chloroform (Slightly), Methanol (Slightly) |
| 外見 | Solid |
| 酸解離定数(Pka) | pKa 11.8 (Uncertain) |
| 色 | Off-White to Light Beige |
| 水溶解度 | 0.95g/L(27℃) |
| CAS データベース | 77-21-4(CAS DataBase Reference) |
| NISTの化学物質情報 | Glutethimide(77-21-4) |
| 主な危険性 | Xn,T,F |
| Rフレーズ | 22-39/23/24/25-23/24/25-11 |
| Sフレーズ | 36-45-36/37-16-7 |
| RIDADR | 3249 |
| WGK Germany | 1 |
| RTECS 番号 | MA4725000 |
| 国連危険物分類 | 6.1(b) |
| 容器等級 | III |
| HSコード | 29251200 |
| 有毒物質データの | 77-21-4(Hazardous Substances Data) |
| 毒性 | Glutethimide, and a structurally similar compound methyprylon, has been used occasionally as a sedative-hypnotic, although glutethimide’s use for longer than 3 days is not recommended and it is rarely, if ever, prescribed today. Glutethimide causes a skin rash in nearly 10% of those using it, and although it was once thought to produce less respiratory depression than the barbiturates its overdose fatality record is not good. Much of the drug’s action can be attributed to 4-hydroxyglutethimide, which is more than twice as potent and has a long half-life. Like many other sedativehypnotics, abrupt withdrawal after chronic use or abuse resembles that of ethanol or the barbiturates and must be managed accordingly. |
