α-(ヒドロキシメチル)ベンゼン酢酸6-ヒドロキシ-8-メチル-8-アザビシクロ[3.2.1]オクタン-3-イル

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H227：引火性液体

  H315：皮膚刺激

  H319：強い眼刺激

• 注意書き

  P210：熱/火花/裸火/高温のもののような着火源から遠ざ けること。－禁煙。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P332+P313：皮膚刺激が生じた場合：医師の診断/手当てを受けるこ と。

  P337+P313：眼の刺激が続く場合：医師の診断/手当てを受けること。

  P370+P378：火災の場合：消火に．．．を使用すること。

  P403+P235：換気の良い場所で保管すること。涼しいところに 置くこと。

  P501：内容物/容器を．．．に廃棄すること。

α-(ヒドロキシメチル)ベンゼン酢酸6-ヒドロキシ-8-メチル-8-アザビシクロ[3.2.1]オクタン-3-イル 価格

α-(ヒドロキシメチル)ベンゼン酢酸6-ヒドロキシ-8-メチル-8-アザビシクロ[3.2.1]オクタン-3-イル 化学特性,用途語,生産方法

• 説明

  Amisodamine is a kind of alkaloid which is mainly living in anisodus tanguticus, which is a M receptor just like Atropine. It is a kind of traditional Chinese medicine which comes from the “National assembly of Chinese Herbal medicine”, and it is the alias of zangjia registered in “Chines herbal medicine summary of shan gan ning qing”. It is a perennial root herb that lives in the bottom slope in the eastern Tibet, Qinghai Province, the Southern GanSu Province, the western SiChuan Province, the northwestward YunNan Province. Since the sources is scare, racemic form of raceanisodamine is the main drug in clinic.

• 物理的性質

  Appearance: raceanisodamine is a kind of white crystal and crystalline powder. It is odorless and bitter to the taste. Solubility: it is easy dissolubility in hydrochloric acid and ethyl alcohol and is soluble in water. Melting point: it’s melting point is from 103 to 113?°C.?The weld spacing is within 6°. Specific optical rotation: ?9° to +11°.

• 来歴

  It is the traditional Chinese medicine and the rich folk herbs that create favorable conditions to look for and develop good medicine. Dated from ancient times, anisodus tanguticus used to the treatment of pain. Unfortunately, it can lead to atropine poisoning resulted from large dosage. When found the adverse effects, research made analysis and finally discovered six kinds of ramifications. Besides, they found two types alkaloid anisodamine and anisodine. Compared with atropine, anisodamen has one more hydroxy in tropic ring and named “654”.

• 使用

  anticholinergic, antispasmodic

• 適応症

  Anisodamine is a kind of anticholinergic agent. The tablet and injection form are mainly used to relieve smooth muscle spasm, biliary spasm and AOIP in clinical practice. The eye drop is used to treat teenage pseudomyopia; raceanisodamine concomitant with other drugs to treat cluster headache syndrome, renal colic, infantile diarrhea, infantile jaundice hepatitis, infantile purpura, bronchopneumonia, etc.

• 薬理学

  1. Cholinolytic effect. Anisodamine can block acetylcholine receptors. We always take it as a merely blocker of M receptor. In recent years, it turns out that anisodamine is also a blocker of N receptor.
  2. Calcium antagonist effect. Anisodamine will put up Clacium antagonist effect when ischemia, oxygen deficit or other reasons result in irreversible damage and apoptosis. 3. Reduce the level of NO. 50 mg/L anisodamine can restrain lipopolysaccharide combined with vascular endothelial cells and promote the production of NO and over-dosage of NO is the pivotal pathologic mechanism of the toxic shock . Pretreatment with anisodamine can reduce the level of NO obviously when cells are damaged and remit toxicity resulted from over-dosage of NO. 4. Anti-oxygenation. anisodamine can restrain myocardial function damage resulted from pyrogallol obviously and can adjust the function of cardioid damaged by ROS .

• 臨床応用

  Anisodamine is a new drug developed by Chinese scientists. It has been widely put into use in clinical practice such as slow reflow phenomenon of ST-elevation acute myocardial infarction patients with percutaneous coronary intervention, infusion leakage , neonatal sclerosis. At present, it is mainly used to dilate vessels, remove vasospasm, improve blood circulation, increase tolerance of ischemia hypoxia and reduce the probability of the surrounding tissue necrosis

α-(ヒドロキシメチル)ベンゼン酢酸6-ヒドロキシ-8-メチル-8-アザビシクロ[3.2.1]オクタン-3-イル 生産企業

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