(±)-ORG 28611

(±)-ORG 28611 化学特性,用途語,生産方法

• 説明

  (±)-ORG 28611 is the racemic mixture of the water soluble, full agonist of the human cannabinoid (CB) receptors central CB₁ (pEC₅₀ = 7.6; pK_i = 8.9) and peripheral CB₂ (pK_i = 8.8). ORG 28611 (0.1-1 μM/kg, intravenous) demonstrated antinociceptive activity in the mouse tail flick test and the mouse formalin paw test, and it was further evaluated clinically for use as a potential intravenous analgesic agent.

• 使用

  (±)-ORG 28611 is full agonist of the human cannabinoid (CB) receptors central CB1 (pEC50 = 7.6; pKi = 8.9) and peripheral CB2 (pKi = 8.8). ORG 28611 (0.1-1 μM/kg, intravenous) demonstrated antinociceptive activity in the mouse tail flick test and the mouse formalin paw test, and it was further evaluated clinically for use as a potential intravenous analgesic agent. Synthetic Cannabinoids

(±)-ORG 28611 生産企業

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