(2S,5R)-3,3-ジメチル-6α-[[(5-メチル-3-フェニルイソオキサゾール-4-イル)カルボニル]アミノ]-7-オキソ-4-チア-1-アザビシクロ[3.2.0]ヘプタン-2β-カルボン酸ナトリウム

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H334：吸入するとアレルギー、喘息または、呼吸困難 を起こすおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P285：換気が十分でない場合には、呼吸用保護具を着用する こと。

  P304+P341：吸入した場合：呼吸が困難な場合には、空気の新鮮な場 所に移し、呼吸しやすい姿勢で休息させること。

  P342+P311：呼吸に関する症状が出た場合：医師に連絡すること。

  P501：内容物/容器を．．．に廃棄すること。

(2S,5R)-3,3-ジメチル-6α-[[(5-メチル-3-フェニルイソオキサゾール-4-イル)カルボニル]アミノ]-7-オキソ-4-チア-1-アザビシクロ[3.2.0]ヘプタン-2β-カルボン酸ナトリウム 価格

(2S,5R)-3,3-ジメチル-6α-[[(5-メチル-3-フェニルイソオキサゾール-4-イル)カルボニル]アミノ]-7-オキソ-4-チア-1-アザビシクロ[3.2.0]ヘプタン-2β-カルボン酸ナトリウム 化学特性,用途語,生産方法

• 化学的特性

  Crystalline

• 使用

  Oxacillin sodium salt is a narrow spectrum beta-lactam antibiotic. It can be used in analytical study of combination of reversed phase liquid chromatography and zwitterion exchange-reversed phase-hydrophilic interaction mixed-mode liquid chromatography coupled with mass spectrometry for anal. of antibiotics and their impurities.

• 臨床応用

  Oxacillin sodium, (5-methyl3-phenyl-4-isoxazolyl)penicillinsodium monohydrate (Prostaphlin), is the salt of a semisyntheticpenicillin that is highly resistant to inactivation bypenicillinase. Apparently, the steric effects of the 3-phenyland 5-methyl groups of the isoxazolyl ring prevent the bindingof this penicillin to the β-lactamase active site and,thereby, protect the lactam ring from degradation in muchthe same way as has been suggested for methicillin. It is alsorelatively resistant to acid hydrolysis and, therefore, may beadministered orally with good effect.
  Oxacillin sodium, which is available in capsule form, isreasonably well absorbed from the gastrointestinal (GI)tract, particularly in fasting patients. Effective plasma levelsof oxacillin are obtained in about 1 hour, but despite extensiveplasma protein binding, it is excreted rapidly throughthe kidneys. Oxacillin experiences some first-pass metabolismin the liver to the 5-hydroxymethyl derivative. Thismetabolite has antibacterial activity comparable to that ofoxacillin but is less avidly protein bound and more rapidlyexcreted. The halogenated analogs cloxacillin, dicloxacillin,and floxacillin experience less 5-methyl hydroxylation.
  The use of oxacillin and other isoxazolylpenicillinsshould be restricted to the treatment of infections causedby staphylococci resistant to penicillin G. Although theirspectrum of activity is similar to that of penicillin G, theisoxazolylpenicillins are, in general, inferior to it and thephenoxymethylpenicillins for the treatment of infectionscaused by penicillin G-sensitive bacteria. Because isoxazolylpenicillinscause allergic reactions similar to thoseproduced by other penicillins, they should be used withgreat caution in patients who are penicillin sensitive.

• 純化方法

  This antibiotic, which is stable to penicillinase, is purified by recrystallisation from isoPrOH and dried in vacuo. Its solubility in H2O at 25o is 5%. [Doyle et al. Nature 192 1183 1961, Review: Chain et al. Antibiotics (Oxford University Press) 2 1949.]

(2S,5R)-3,3-ジメチル-6α-[[(5-メチル-3-フェニルイソオキサゾール-4-イル)カルボニル]アミノ]-7-オキソ-4-チア-1-アザビシクロ[3.2.0]ヘプタン-2β-カルボン酸ナトリウム 上流と下流の製品情報

(2S,5R)-3,3-ジメチル-6α-[[(5-メチル-3-フェニルイソオキサゾール-4-イル)カルボニル]アミノ]-7-オキソ-4-チア-1-アザビシクロ[3.2.0]ヘプタン-2β-カルボン酸ナトリウム 生産企業

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