2-[[2-(4-エチルフェニル)-5-メチル-4-オキサゾリル]メチルチオ]-N-フェネチルアセトアミド

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H302：飲み込むと有害

  H315：皮膚刺激

  H318：重篤な眼の損傷

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

2-[[2-(4-エチルフェニル)-5-メチル-4-オキサゾリル]メチルチオ]-N-フェネチルアセトアミド 価格

2-[[2-(4-エチルフェニル)-5-メチル-4-オキサゾリル]メチルチオ]-N-フェネチルアセトアミド 化学特性,用途語,生産方法

• 使用

  iCRT3, is an inhibitor of both Wnt and β-catenin-responsive transcription (CRT).

• 一般的な説明

  iCRT3 is a small cell-permeable oxazole compound. It blocks cytokine secretion in lipopolysaccharide (LPS)-stimulated macrophages.

• Biochem/physiol Actions

  The key mediator of Wnt signaling is the transcriptional co-activator b-catenin. In the cytoplasm, b-catenin is tightly bound to a complex that includes Axin and GSK-3b. Stimulation causes b-catenin stabilization, translocation to the nucleus and association with TCF4 to initiate transcription of responsive genes, referred to as Catenin Responsive Transcription (CRT). Virtually all Wnt-associated cancers are the result of misregulated CRT. Three inhibitors of CRT (iCRT) were identified in a screen that employed RNAi based knockdown of Axin, which stimulates CRT without affecting upstream mechanisms such as GSK activity, transduction by disheveled / frizzled, etc. These compounds are potent inhibitors of CRT reporter genes, as well as endogenous gene targets. The compounds also disrupt b-catenin-TCF4 interaction in a dose dependent manner, and cause G0/G1 arrest in colon tumor lines.

2-[[2-(4-エチルフェニル)-5-メチル-4-オキサゾリル]メチルチオ]-N-フェネチルアセトアミド 生産企業

Global(45)Suppliers