ニクズク核油

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H226：引火性の液体および蒸気

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

ニクズク核油 価格

ニクズク核油 化学特性,用途語,生産方法

• 定義

  本品は、ニクズク Myristica fragrans の核から得られる油である。

• 化粧品の成分用途

  皮膚コンディショニング剤、香料、香味剤

• 説明

  Evergreen tree 15 to 20 m (49 to 66 ft.) in height; grows in Java, Sumatra, Borneo, Penang, Moluccas, and in several other islands of the Indian Ocean. It has alternate leaves and dioecious flowers. Consequently, only female trees bear nuts; male plants are interdispersed in the groves only to ensure pollination. The ripe fruits are yellow-red with a fleshy pericarp; the red arillode is tightly wrapped around a woody hull containing the seed.
  Note: Mace designates the dried arillodes of nutmeg. The ratio of nutmegs to mace is approximately 10:1. Nutmeg and mace yield different, but sometimes similar, products.
  The parts used are the nuts (free of the outer pulp) and arillodes (decolorized with lime). The most commercially important qualities of nutmeg and mace follow:
  ? Banda nutmeg and Banda mace contain 8% and 13% essential oil, respectively;
  ? Java nutmeg and Java mace contain 6.5% and 11% essential oil, respectively; and
  ? Siauw nutmeg and Siauw mace contain 6.5% and 10 to 12% essential oil, respectively.
  These qualities are further subdivided according to size-large, medium, and small-for extraction and according to appearance- whole, worm-eaten, etc.

• 化学的特性

  The oil is obtained by steam distillation of dried comminuted nutmeg previously treated by hydraulic expression to remove fixed oils; yields are approximately 12%. The hot expression of nutmeg yields a fatty oil with a melting point of about 45°C. Two types of oils, the East Indian and West Indian, are commercially available. The oil exhibits a characteristic nutmeg odor.

• 物理的性質

  Nutmeg essential oil is a colorless to pale-yellow liquid. It is soluble in alcohol.

• 天然物の起源

  Found in the fruit of Myristica fragrans Houtt. (Fam. Myristicaceae) (Gildemeister & Hoffman, 1956; Guenther, 1952).

• 使用

  As a cooking spice, flavoring in food and beverages. Nutmeg oil as fragrance in soaps, detergents, creams, lotions, perfumes. Fixed oil in candles.

• 製造方法

  By steam distillation of the dried nutmeg (Guenther, 1952).

• 精油の成分

  The oil contains α- and γ-pinene, camphene, dipentene, p-cymene, d-linalool, terpineol, geraniol, safrole, eugenol and isoeugenol.

• 薬理学

  The principal pharmacologically active component of nutmeg, myristicin, caused ataxia and disorientation in monkeys and enhanced morphine-induced rage in cats (Truitt et al 1961). Doses of 400 mg on alternate days produced in normal volunteers some evidence of slight euphoria, but none resembling the symptoms of excitation seen in acute nutmeg poisoning (Truitt et al 1961).

• 安全性プロファイル

  Moderately toxic by ingestion. Low toxicity by skin contact. An experimental teratogen. Experimental reproductive effects. Mutation data reported. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

• 代謝

  Nutmeg demonstrates a mild degree of monoamine oxidase (MAO)-inhibiting activity in vitro and in vivo (Truitt, 1967; Truitt & Ebersberger, 1962). In a test based on interference with tryptamine metabolism, nutmeg was shown to possess a weak enzyme-inhibitory action, but inhibition by myristicin was approximately one third as powerful as that of iproniazid, a well known antidepressant of this class (Truitt & Ebersberger, 1962). When oral doses of 0.2 or 1.0 g/kg nutmeg powder (as an acacia suspension) were given to mice and rats, the onset of the inhibiting action was first noted 17-24 hr after feeding as a lowering of the convulsive threshold in mice following iv injection of tryptamine. In rats, after the tryptamine injection, the MAO inhibition took the form of an increase in concentration of 5-hydroxytryptamine in the brain (Truitt, Duritz & Ebersberger, 1963).

ニクズク核油 生産企業

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