抗Β-アミロイドタンパク質(1-40)抗体 ウサギ宿主抗体

抗Β-アミロイドタンパク質(1-40)抗体 ウサギ宿主抗体 化学特性,用途語,生産方法

• 使用

  Anti-β-Amyloid Protein (1-40) antibody produced in rabbit has been used in:
  
  • immunocytochemical localization of Aβ peptides
  • immunocytochemistry
  • immunoprecipitation
  • focused ultrasound-microbubble enhanced antibody delivery (FUS-MB)
  
  

• 一般的な説明

  Amyloid precursor proteins (APPs) are members of a large family of 70 kDa transmembrane glycoproteins that are found in a wide range of tissues. APP is expressed in the brain. It is located on human chromosome 21. APPs have three main isoforms, namely, APP₆₉₅, APP₇₅₁ and APP₇₇₀, that are derived from alternative splicing events in cells.

• Biochem/physiol Actions

  The β-amyloid precursor protein (APP) is cleaved sequentially by the proteolytic enzymes β-secretase (BACE1) and γ-secretase to produce β-amyloid (Aβ) peptides with the Aβ1-42 and the Aβ1-40 forms being the most prevalent. Secreted Aβ peptides are degraded either via a re-uptake mechanism followed by endosomal degradation, or by an extracellular insulin degrading enzyme. Extracellular accumulation of Aβ leads to the formation of aggregates, fibrils and eventually amyloid deposits called neuritic plaques, which is the hallmark of Alzheimer′s disease (AD).Rabbit Anti-β-Amyloid Protein (1-40) antibody does not stain control sections of normal brain tissues.

抗Β-アミロイドタンパク質(1-40)抗体 ウサギ宿主抗体 生産企業

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