ブドウ果実

化学名:ブドウ果実

CAS番号.84929-27-1

英語名:Grape Seed Extract

CBNumberCB6258001

MFC32H30O11

MW590.574

MOL File84929-27-1.mol

别名

ブドウエキス

ブドウ葉エキス

ブドウ種子/皮/茎エキス

ブドウ果実物理性質

比重(密度)	0.961g/cm3 at 20℃
蒸気圧	0.003Pa at 60℃
FEMA	4045 \| GRAPE SEED EXTRACT
貯蔵温度	Inert atmosphere,Room Temperature
溶解性	Soluble in DMSO
外見	Solid:particulate/powder
色	Brown to reddish brown
InChIKey	VWKAFYWVDIOMSL-PSXRJWADNA-N
SMILES	[C@H]1(C2=CC=C(O)C(O)=C2)OC2=C(C(O)=CC(O)=C2)[C@@H](C2C3O[C@H](C4=CC=C(O)C(O)=C4)[C@@](O)(C)CC=3C(C)=CC=2O)[C@@H]1O \|&1:0,18,22,31,41,r\|
LogP	6.5 at 25℃ and pH5-6

危険有害性情報のコード(GHS)

ブドウ果実化学特性,用途語,生産方法

定義
本品は、ブドウ Vitis vinifera の果実を蒸留して得られる芳香成分を含む水である。
化粧品の成分用途
エモリエント剤、結合剤、抗う蝕剤、抗フケ剤、抗菌剤、抗黴剤、口腔ケア剤、口腔衛生剤、皮膚コンディショニング剤、酸化防止剤、褪色防止剤、香料、香味剤、着色剤、紫外線吸収剤.散乱剤
化学的特性
Grape seed extract has an astrigent taste.
天然物の起源
Grapeseed is found throughout the world.
使用
Grape seed extract is a natural product, with anti-inflammatory and anti-proliferative effects. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase. Grape seed extract induces apoptotic in human colorectal cancer cells.
抗がん研究
Grape seed extract (GSE) has high quantities of proanthocyanidins and resveratrol.Human colorectal cancer cell (CRC) exposure to GSE (Schonthal 2012) resulted inmodified ER chaperones glucose-related protein-78 (GRP78) and protein disulphideisomerase (PDI). GRP78 is needed for integrity of ER as well as stress-inducedautophagy (Flaumenhaft et al. 2015). PDI, a thiol-disulphide oxidoreductase,catalyses the disulphide bonds in newly synthesized proteins in the ER lumen (Hanet al. 2013; Wang and Kaufman 2014; Perri et al. 2016), and PDIA3 is localized tothe ER and is involved in protein folding (Wang et al. 2012b). Studies on the role ofPDI in cancer have demonstrated a pro-oncogenic, pro-survival role for PDI incancer and therapeutic resistance. PDI aids in ameliorating stress-induced apoptosisand causes degradation of wrongly folded proteins (Dinicola et al. 2010; Xu et al.2014). Hence, any obstruction caused in the activity of PDI will induce stress in thecell and lead to cell apoptosis. Fructose bisphosphate aldolase, a key enzymeinvolved in glycolysis, is also a potential target of GSE (Vandewynckel et al. 2016).The ER stress leads the cell to undergo apoptotic pathways in multiple ways andhence inhibits the proliferation of the targeted cells (Farooqi et al. 2015).
安全性
Grape seed extract is generally well tolerated when taken in moderate amounts. It has been tested safely for up to 11 months in human studies. It’s possibly unsafe if you have a bleeding disorder or are going to have surgery or if you take anticoagulants (blood thinners), such as warfarin or aspirin. Little is known about whether it’s safe to use grape seed extract during pregnancy or while breastfeeding.

ブドウ果実生産企業

84929-27-1, ブドウ果実キーワード

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ブドウ果実

危険有害性情報のコード(GHS)

ブドウ果実 化学特性,用途語,生産方法

ブドウ果実 生産企業

84929-27-1, ブドウ果実 キーワード

ブドウ果実化学特性,用途語,生産方法

ブドウ果実生産企業

84929-27-1, ブドウ果実キーワード