メフロキン塩酸塩

化学名:メフロキン塩酸塩

CAS番号.51773-92-3

英語名:Mefloquine hydrochloride

CBNumberCB6252498

MFC17H17ClF6N2O

MW414.77

MOL File51773-92-3.mol

别名

メフロキン塩酸塩

塩酸メフロキン

rac-(R*)-α-[(2S*)-2-ピペリジル]-2,8-ビス(トリフルオロメチル)-4-キノリンメタノール/塩酸,(1:1)

メフロキン塩酸塩物理性質

融点	250-254?C
貯蔵温度	2-8°C
溶解性	DMSO: 38 mg/mL、可溶
外見	個体
色	白い
極大吸収波長 (λmax)	222nm(Acidic H2O)(lit.)
Merck	14,5801
BCS Class	4/2
安定性：	温度に敏感
InChI	InChI=1/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/s3
InChIKey	WESWYMRNZNDGBX-YLCXCWDSSA-N
SMILES	C12N=C(C=C([C@@H](O)[C@@]3([H])NCCCC3)C=1C=CC=C2C(F)(F)F)C(F)(F)F.Cl \|&1:5,7,r\|
CAS データベース	51773-92-3(CAS DataBase Reference)

安全性情報

主な危険性	Xn
Rフレーズ	22
RIDADR	UN 3077 9 / PGIII
WGK Germany	3
RTECS 番号	VC0308000
HSコード	2933399090

危険有害性情報のコード(GHS)

メフロキン塩酸塩価格

製品番号	包装	価格	製品説明	購入
富士フイルム和光純薬株式会社(wako) W01APOPC404546	1g	￥37000		購入
富士フイルム和光純薬株式会社(wako) W01APOPC404546	5g	￥139700		購入
東京化成工業 M2313	1g	￥14300	メフロキン塩酸塩 >98.0%(HPLC)	購入
Sigma-Aldrich Japan M0253000	m0253000	￥19400	メフロキン塩酸塩 European Pharmacopoeia (EP) Reference Standard	購入
Sigma-Aldrich Japan 1379059	100mg	￥60800	メフロキン塩酸塩 United States Pharmacopeia (USP) Reference Standard	購入

MSDS Information

メフロキン塩酸塩化学特性,用途語,生産方法

外観
白色～ほとんど白色粉末～結晶
効能
抗マラリア薬
商品名
メファキン (久光製薬)
説明
Mefloquine hydrochloride is an erythrocytic schizonticide useful, in combination with sulfadoxine and pyrimethamine, in the prophylaxis and treatment of malaria. Administered once weekly, the combination is effective against pathogens resistant to other agents.
化学的特性
White Solid
使用
Mefloquine Hydrochloride (Polymorph Form E) is a polymorphic form of Mefloquine Hydrochloride (M207055), a quinoline methanol antimalarial agent.
一般的な説明
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards
臨床応用
The newest of the 4-aminoquinolines,mefloquine, is marketed as the R,S-isomer. It was developedin the 1960s as part of the U.S. Army’s WalterReed Institute for Medical Research antimalarial researchprogram. It differs significantly from the other agents in this class by having two trifluromethyl moieties at positions2’ and 8' and no electronegative substituents at eitherpositions 6' (quinine) or 7' (chloroquine). Mefloquine alsodiffers from chloroquine and its analogs by being a schizonticide acting before the parasite canenter the erythrocyte. There is some evidence that it acts byraising the pH in the parasite’s vesicles interfering with itsability to process heme. Mefloquine-resistant strains ofP. falciparum have appeared. Relapse can occur with acuteP. vivax that has been treated with mefloquine because thedrug does not eliminate the hepatic phase of this species,which can reinfect the liver.
Mefloquine is teratogenic in rats, mice, and rabbits. Thereis an FDA-required warning that this drug can cause exacerbatemental disorders and is contraindicated in patients withactive depression, a recent history of depression, generalizedanxiety disorder, psychosis, schizophrenia, and other majorpsychiatric disorders or a history of convulsions.

メフロキン塩酸塩生産企業

メフロキン塩酸塩スペクトルデータ(MS)

51773-92-3, メフロキン塩酸塩キーワード

Send Inquriy

メフロキン塩酸塩

危険有害性情報のコード(GHS)

メフロキン塩酸塩 価格

MSDS Information

メフロキン塩酸塩 化学特性,用途語,生産方法

メフロキン塩酸塩 生産企業

メフロキン塩酸塩 スペクトルデータ(MS)

51773-92-3, メフロキン塩酸塩 キーワード

メフロキン塩酸塩価格

メフロキン塩酸塩化学特性,用途語,生産方法

メフロキン塩酸塩生産企業

メフロキン塩酸塩スペクトルデータ(MS)

51773-92-3, メフロキン塩酸塩キーワード