13,14-ジヒドロ-2',14β-ジヒドロキシ-4'',5''-ジメトキシリトラン-12-オン

13,14-ジヒドロ-2',14β-ジヒドロキシ-4'',5''-ジメトキシリトラン-12-オン 化学特性,用途語,生産方法

• 説明

  Both Heirnia rnyritifolia Cham. et Schl. and H. salicifolia Link & Otto yield this macrocyc1ic alkaloid which may be crystallized from a mixture of AcOEt, MeOH and light petroleum as glistening needles. Two somewhat different values for the specific rotation have been recorded, viz. [α]²⁵_D - 174.2° (c 0.3325, CHC13) by Blomster and [α]²⁵_D - 153.4° (c 0.3, CHCI3) by Douglas. The ultraviolet spectrum exhibits a broad absorption maximum at 292 mil and an inflexion at 250 mil. Two methoxyl groups, a secondary and a phenolic hydroxyl group are present. The hydrochloride yields colourless crystals from MeOH, m.p. 330°C (dec.). The structure has been determined mainly from the infrared and mass spectra.

• 参考文献

  Douglas et ai., L/oydia, 27, 25 (1964) Blomster, Schwarting, Bobbitt., ibid, 27, 15 (1964) Absolute configuration: Chu et ai., Chern. Ind., 1795 (1966) Mass spectrum: Appel, Achenbach., Tetrahedron Lett., 5789 (1966) Structure: Ferris, Boyce, Briner., J. Arner. Chern. Soc., 93, 2942 (1971) Ferris et ai., ibid, 93, 2963 (1971)

13,14-ジヒドロ-2',14β-ジヒドロキシ-4'',5''-ジメトキシリトラン-12-オン 生産企業

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