3-シアノ-2-アミノプロピオン酸

3-シアノ-2-アミノプロピオン酸 化学特性,用途語,生産方法

• Synthesis Reference(s)

  Tetrahedron, 22, p. 2303, 1966 DOI: 10.1016/S0040-4020(01)82149-9

• 代謝

  In the living plant, 3-cyanoalanine is mainly bound as its gama-glutamyl derivative. The enzyme, beta-cyanoalanine synthase, catalysing the reaction between cysteine and cyanide has been isolated from seedlings of the blue lupin (Lupinus angustifolius, Leguminosae).
  3-Cyanoalanine is a neurotoxin, causing convulsions and muscular rigidity in rats and chicks. In rats, the compound also causes cystathioninuria, the lethai dose being 20mg/100g body weight. This metabolic defect can be prevented by injection of pyridoxal phosphate. Thus, beta-cyanoalanine interferes with pyridoxal metabolism and inhibits the enzyme gama-cystathionase.
  In non-accumulating plants, 3-cyanoalanine is enzymatically hydrolysed to the protein amino acid, asparagine, by 3-cyanoalanine hydrolase. Thus, this nonprotein amino acid could be a ubiquitous constituent of plants, but may only accumulate in those species whieh do not contain 3-cyanoalanine hydrolase.

3-シアノ-2-アミノプロピオン酸 生産企業

Global(1)Suppliers