10,11-ジヒドロ-α,8-ジメチル-11-オキソジベンゾ[b,f]オキセピン-2-酢酸

10,11-ジヒドロ-α,8-ジメチル-11-オキソジベンゾ[b,f]オキセピン-2-酢酸 化学特性,用途語,生産方法

• Originator

  Bermoprofen,ZYF Pharm Chemical

• Manufacturing Process

  A mixture of dl-2-[4-(2'-carboxymethyl-4'-methylphenoxy)phenyl]propionic acid (15.3 g) and polyphosphoric acid (92 g) was heated with stirring at 110- 120°C for 2 hours. To the reaction mixture was added water and the resulting mixture was extracted with chloroform. The organic layer was washed with water, dried over anhydrous sodium sulfate and concentrated. The residue was chromatographed on silica gel (75 g) using chloroform as an eluent to give a crude product, which was recrystallized from toluene to give the dl-2-(8- methyl-10,11-dihydro-11-oxodibenz[b,f]oxepin-2-yl)propionic acid (9.4 g, 65.3%), m.p. 128-129°C.

• Therapeutic Function

  Antiinflammatory, Antipyretic

10,11-ジヒドロ-α,8-ジメチル-11-オキソジベンゾ[b,f]オキセピン-2-酢酸 上流と下流の製品情報

10,11-ジヒドロ-α,8-ジメチル-11-オキソジベンゾ[b,f]オキセピン-2-酢酸 生産企業

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